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α-N-Benzoyl-2-cyano-L-histidine Amide is a complex organic compound with the chemical formula C15H15N5O3. It is a derivative of L-histidine, an essential amino acid, where the α-amino group is acylated with a benzoyl group, and the imidazole ring is substituted with a cyano group. α-N-Benzoyl-2-cyano-L-histidine Amide is known for its potential applications in medicinal chemistry, particularly in the development of histamine receptor antagonists. It is characterized by its white crystalline appearance and is often used in research settings to study the structure-activity relationships of histidine-based compounds. The amide functionality in the molecule allows for potential hydrogen bonding interactions, which can be crucial in its biological activity and binding properties.

74419-69-5

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74419-69-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 74419-69-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,4,1 and 9 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 74419-69:
(7*7)+(6*4)+(5*4)+(4*1)+(3*9)+(2*6)+(1*9)=145
145 % 10 = 5
So 74419-69-5 is a valid CAS Registry Number.

74419-69-5Relevant academic research and scientific papers

New Histamine and Histidine Analogues via Transformations of the 2-Trifluoromethyl Group

Kimoto, Hiroshi,Cohen, Louis A.

, p. 3831 - 3835 (2007/10/02)

α-N-Benzoyl-2-(trifluoromethyl)histamine has been transformed, via a difluorodiazafulvene intermediate, into 2-carboxy- and 2-(carbomethoxy)histamine. 2-Carboxy-L-histidine was prepared by a similar route. 2-(Carbomethoxy)-L-histidine was prepared by methanolysis of α-N-(tert-butoxycarbonyl)-2-(trifluoromethyl)-L-histidine and acid hydrolysis of the intermediate ortho ester. 2-Cyanohistamine and 2-cyano-L-histidine are best prepared by ammonolysis of the corresponding α-N-(tert-butoxycarbonyl)-2-(trifluoromethyl)imidazoles and acid cleavage of the protecting group.During the hydrolysis of N-benzoyl protecting groups in hot, aqueous mineral acid, decarboxylation of 2-carboxyimidazoles occurs gradually; this side reaction is repressed by use of concentrated acid.

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