74420-07-8 Usage
Uses
Used in Pharmaceutical Industry:
1H-Pyrrolo[2,3-b]pyridine, 3-nitro-, 7-oxide is used as a therapeutic agent for the treatment of conditions involving excessive nitric oxide production. Its potent and selective inhibition of nitric oxide synthesis makes it a valuable asset in managing septic shock and inflammation, where uncontrolled nitric oxide production can lead to severe complications.
Used in Medicinal Chemistry Research:
1H-Pyrrolo[2,3-b]pyridine, 3-nitro-, 7-oxide serves as a key compound in medicinal chemistry research, where it is utilized to explore and understand the mechanisms of nitric oxide synthesis and its role in various physiological and pathological processes. This knowledge can contribute to the development of new therapeutic strategies and drug candidates targeting nitric oxide-related pathways.
Used in Drug Discovery:
In the field of drug discovery, 1H-Pyrrolo[2,3-b]pyridine, 3-nitro-, 7-oxide is employed as a lead compound for the development of new therapies. Its unique properties and inhibitory effects on nitric oxide synthesis make it a promising starting point for the design and synthesis of novel drugs that can effectively target nitric oxide-related pathways and address a range of medical conditions.
Overall, 1H-Pyrrolo[2,3-b]pyridine, 3-nitro-, 7-oxide holds significant potential in various applications across the pharmaceutical, medicinal chemistry, and drug discovery industries. Its ability to selectively inhibit nitric oxide synthesis positions it as a valuable tool for the treatment of conditions characterized by excessive nitric oxide production and for the advancement of research in nitric oxide-related pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 74420-07-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,4,2 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 74420-07:
(7*7)+(6*4)+(5*4)+(4*2)+(3*0)+(2*0)+(1*7)=108
108 % 10 = 8
So 74420-07-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N3O3/c11-9-3-1-2-5-6(10(12)13)4-8-7(5)9/h1-4,7-8H/q+1
74420-07-8Relevant articles and documents
Improved synthesis of the selective rho-kinase inhibitor 6-chloro-n4-{3,5-difluoro-4-[(3-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl} pyrimidin-2,4-diamine
Schirok, Hartmut,Paulsen, Holger,Kroh, Walter,Chen, Gang,Gao, Ping
scheme or table, p. 168 - 173 (2010/04/29)
A highly potent and selective Rho-kinase inhibitor containing a 7-azaindole moiety has been developed at Bayer Schering Pharma. Herein we disclose details of a significantly improved synthesis of the compound in 8.2% overall yield. Key aspects include cost and safety considerations and the uncommon use of a trifluoromethyl group with controllable reactivity as a masked methyl group.
Synthesis of 4-Amino-1H-pyrrolopyridine (1,7-Dideazaadenine) and 1H-Pyrrolopyridin-4-ol (1,7-Dideazahypoxanthine)
Schneller, Stewart W.,Luo, Jiann-Kuan
, p. 4045 - 4048 (2007/10/02)
4-Amino-1H-pyrrolopyridine (1,7-dideazaadenine) (5) has been synthesized by the iron and acetic acid reduction of 4-nitro-1H-pyrrolopyridine 7-oxide (13), obtained by nitration of 1H-pyrrolopyridine-3-carboxamide 7-oxide (17).Other nitration reactions in the 1H-pyrrolopyridine 7-oxide series are disclosed.The preparation of 1H-pyrrolopyridin-4-ol (1,7-dideazahypoxanthine) (6) began with the hydrolysis of ethyl 1-benzyl-3-cyano-4-oxo-4,7-dihydro-1H-pyrrolopyridine-5-carboxylate (21) to the 3,5-dicarboxylic acid derivative of 1-benzyl-4-oxo-4,7-dihydro-1H-pyrrolopyridine (22).Decarboxylation of 22 with subsequent debenzylation formed 6.
