74421-77-5Relevant articles and documents
Reaction of quinoline N-oxides with alkyl- and aryllithiums in the presence of oxidant
Tagawa, Yoshinobu,Nomura, Manami,Yamashita, Hiroyuki,Goto, Yoshinobu,Hamana, Masatomo
, p. 2385 - 2397 (2007/10/03)
Quinoline and some 4-substituted quinoline 1-oxides react with alkyl- and aryllithiums in the presence of an oxidant to afford 2-alkyl- and 2- arylquinoline 1-oxides in generally good yields. Among oxidants used, 9- fluorenone is most effective. On the other hand, quinaldine 1-oxide undergoes a base-induced electrophilic reaction with n-BuLi and 9-fluorenone to give 2- [(9-hydroxyfluoren-9-yl)methyl]quinoline 1-oxide.