744217-31-0Relevant academic research and scientific papers
Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections
-
Page/Page column 26, (2015/09/28)
The present invention relates to novel compounds according to the general formulas I, II, III, IV or V: wherein B is nucleoside base according to the structure: and the remaining variables as defined in the specification, and pharmaceutical compositions c
Synthesis of (±)-4′-ethynyl and 4′-cyano carbocyclic analogues of stavudine (d4T)
Kumamoto, Hiroki,Haraguchi, Kazuhiro,Tanaka, Hiromichi,Nitanda, Takao,Baba, Masanori,Dutschman, Ginger E.,Cheng, Yung-Chi,Kato, Keisuke
, p. 73 - 83 (2007/10/03)
The synthesis of (±)-4′-ethynyl (8) and 4′-cyano (9) carbocyclic analogues of the anti-HIV agent stavudine (5, d4T) is reported. The carbocyclic unit (16) was constructed from readily available β-keto ester 10. The ethynyl or cyano group of 8 and 9 were p
