744251-50-1

Basic information

• Product Name: 4-bromo-5-phenyl-2H-1,2,3-triazole
• CAS NO: 744251-50-1
• Molecular Weight: 224.06
• Mol File: 744251-50-1.mol

Chemical Properties

• CAS DataBase Reference: 4-bromo-5-phenyl-2H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-5-phenyl-2H-1,2,3-triazole(744251-50-1)
• EPA Substance Registry System: 4-bromo-5-phenyl-2H-1,2,3-triazole(744251-50-1)

Safety Data

• Hazardous Substances Data: 744251-50-1(Hazardous Substances Data)

Upstream product

• 102-96-5 (2-nitroethenyl)benzene 
• 112614-96-7 4-phenyl-2H-[1,2,3]triazole 

Downstream Products

• 1198613-17-0 C₁₅H₁₀BrF₂N₃ 
• 1198613-15-8 C₁₅H₁₀BrF₂N₃ 
• 1198613-13-6 C₁₅H₁₀BrF₂N₃ 
• 1198613-19-2 C₁₆H₁₄BrN₃O 
• 1198613-22-7 C₁₆H₁₄BrN₃O 
• 1198613-20-5 C₁₆H₁₄BrN₃O 
• 1198613-05-6 C₁₆H₁₄BrN₃ 
• 1198613-01-2 C₁₆H₁₄BrN₃ 
• 1198613-03-4 5-bromo-1-phenethyl-4-phenyl-1H-1,2,3-triazole 
• 1198613-11-4 C₁₄H₁₆BrN₃O₂ 
• 1198613-08-9 C₁₄H₁₆BrN₃O₂ 
• 1198613-09-0 C₁₄H₁₆BrN₃O₂ 
• 1198612-95-1 C₁₀H₁₀BrN₃ 
• 1198612-99-5 C₁₀H₁₀BrN₃ 

Relevant articles and documents

Metal-free, highly regioselective sulfonylation of NH-1,2,3-triazoles with sodium sulfinates and thiosulfonates

A convenient and metal-free protocol for the highly regioselective sulfonylation of NH-1,2,3-triazoles is described. A range of readily accessible NH-1,2,3-triazoles were sulfonylated with various aryl sulfinates in the presence of molecular iodine. The scope was extended to thiosulfonates as an efficient sulfonylating agent and nitrochromene derived triazoles were also explored for selective N-sulfonylation. A variety of synthetically viable N2-sulfonyl triazoles were obtained in moderate to high yields with excellent regioselectivities via N–S bond construction under mild reaction conditions.

Copper-Catalyzed Cross-Dehydrogenative N2-Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N-Amidoalkylation of NH-1,2,3-Triazoles

An efficient copper-catalyzed C-N bond formation by N-H/C-H cross-dehydrogenative coupling (CDC) between NH-1,2,3-triazoles and N,N-dialkylamides has been developed. The method provided N-amidoalkylated 1,2,3-triazoles with moderate to high yields, and th

Method of selectively synthesizing 2-alkyl acylated-4-aryl-1,2,3-triazole compound

The invention relates to a method of selectively synthesizing a 2-alkyl acylated-4-aryl-1,2,3-triazole compound. The method comprises the following steps: (a) introducing a bromine atom to a carbon atom at #5 site of 4-aryl-1,2,3-triazole by means of a br

Bromo-directed N-2 alkylation of NH-1,2,3-triazoles: Efficient synthesis of poly-substituted 1,2,3-triazoles

"Chemical Equation Presented" Reaction of 4-bromo-NH-1,2,3- triazoles 2 with alkyl halides In the presence of K2CO3 in DMF produced the corresponding 2-substituted 4-bromo1,2,3-triazoles 5 In a regioselective process. Subsequent Suzuki cross-coupling reaction of these bromides provided an efficient synthesis of 2,4,5-trisubstituted triazoles 3. In addition, reduction of the bromotriazoles by hydrogenation furnished an efficient synthesis of 2,4-disubstituted triazoles 8.

Macrocyclic hepatitis C serine protease inhibitors

The present invention relates to compounds of Formula I, II or Ill, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.