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744261-45-8

744261-45-8

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744261-45-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 744261-45-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,4,2,6 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 744261-45:
(8*7)+(7*4)+(6*4)+(5*2)+(4*6)+(3*1)+(2*4)+(1*5)=158
158 % 10 = 8
So 744261-45-8 is a valid CAS Registry Number.

744261-45-8Downstream Products

744261-45-8Relevant articles and documents

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1

Westaway, Susan M.,Thompson, Mervyn,Rami, Harshad K.,Stemp, Geoffrey,Trouw, Leontine S.,Mitchell, Darren J.,Seal, Jon T.,Medhurst, Stephen J.,Lappin, Sarah C.,Biggs, James,Wright, James,Arpino, Sandra,Jerman, Jeffrey C.,Cryan, Jennifer E.,Holland, Vicky,Winborn, Kim Y.,Coleman, Tanya,Stevens, Alexander J.,Davis, John B.,Gunthorpe, Martin J.

scheme or table, p. 5609 - 5613 (2009/06/18)

6-Phenylnicotinamide (2) was previously identified as a potent TRPV1 antagonist with activity in an in vivo model of inflammatory pain. Optimization of this lead through modification of both the biaryl and heteroaryl components has resulted in the discovery of 6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazol-5-yl)nicotinamide (32; SB-782443) which possesses an excellent overall profile and has been progressed into pre-clinical development.

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