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2,3,4,6-tetra-O-acetyl-N,N-bis(2-chloroethyl)-D-glucopyranosylamine is a chemical compound derived from D-glucopyranosylamine, featuring four acetyl groups and two chloroethyl groups. This structural modification endows it with potent alkylating properties, allowing it to form covalent bonds with DNA and induce cell death, particularly in cancer cells.

74427-64-8

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74427-64-8 Usage

Uses

Used in Oncology:
2,3,4,6-tetra-O-acetyl-N,N-bis(2-chloroethyl)-D-glucopyranosylamine is used as an anticancer agent for its ability to selectively target and disrupt the DNA structure of cancer cells, making it a promising candidate for the treatment of malignant lymphoma and leukemia.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2,3,4,6-tetra-O-acetyl-N,N-bis(2-chloroethyl)-D-glucopyranosylamine is utilized in the research and development of novel anticancer drugs due to its alkylating capabilities and potential to cause cell death in cancerous cells. Further clinical development and research are necessary to explore its full therapeutic potential and safety profile.

Check Digit Verification of cas no

The CAS Registry Mumber 74427-64-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,4,2 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 74427-64:
(7*7)+(6*4)+(5*4)+(4*2)+(3*7)+(2*6)+(1*4)=138
138 % 10 = 8
So 74427-64-8 is a valid CAS Registry Number.

74427-64-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name [3,4,5-triacetyloxy-6-[bis(2-chloroethyl)amino]oxan-2-yl]methyl acetate

1.2 Other means of identification

Product number -
Other names D-Glucopyranosylamine,N-bis(2-chloroethyl)-,2,3,4,6-tetraacetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74427-64-8 SDS

74427-64-8Upstream product

74427-64-8Downstream Products

74427-64-8Relevant academic research and scientific papers

Synthesis and biological activity of nitrogen mustards carbohydrate derivatives

Moruzzi,Montero,Imbach

, p. 125 - 132 (2007/10/02)

The authors describe the synthesis of N,N-bis(2-chloroethyl) amine carbohydrate derivatives, using sugar moieties previously associated with other oncostatic agents. The structure of these compounds was determined using 1H and 13C NMR spectroscopy. Their antitumor activity on L1210 on mice and their immunodepressive effects have been evaluated.

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