74428-44-7

Upstream product

• 29444-53-9 2-methyl-3-phenyl pyrazine 
• 83520-46-1 2-Chloromethyl-3-phenylpyrazine 
• 83520-62-1 2-Cyanomethyl-3-phenylpyrazine 
• 579-07-7 1-Phenylpropane-1,2-dione 

Downstream Products

• 74428-45-8 2-Methyl-3-phenylpyrazine 4-Oxide 
• 83520-61-0 2-Hydroxymethyl-3-phenylpyrazine 
• 83520-45-0 5-Chloro-2-methyl-3-phenylpyrazine 
• 79137-42-1 5-Hydroxy-2-methyl-3-phenylpyrazine 
• 83520-62-1 2-Cyanomethyl-3-phenylpyrazine 
• 83520-52-9 6-Methyl-4-oxy-5-phenyl-1H-pyrazin-2-one 
• 83520-44-9 2-Methyl-3-phenylpyrazine 1,4-Dioxide 
• 83520-47-2 6-Chloro-2-methyl-3-phenylpyrazine 4-Oxide 
• 83520-56-3 2-Chloromethyl-3-phenylpyrazine 1-Oxide 
• 83520-49-4 5-Chloro-2-methyl-3-phenylpyrazine 1-Oxide 
• 83520-51-8 6-Methoxy-2-methyl-3-phenylpyrazine 4-Oxide 
• 83520-55-2 2-Chloromethyl-3-phenylpyrazine 4-Oxide 
• 83520-48-3 6-Chloro-2-methyl-3-phenylpyrazine 1,4-Dioxide 
• 83520-53-0 Dimethyl-(6-methyl-4-oxy-5-phenyl-pyrazin-2-yl)-amine 

Relevant academic research and scientific papers

Synthesis of tetrasubstituted pyrazines and pyrazine N-oxides

An efficient synthesis of tetrasubstituted unsymmetrical pyrazines and their related pyrazine N-oxides has been developed from commercially available 2-chloro-3-methylpyrazine. The procedure and scope of these synthesis routes are described.

Syntheses and Reactions of Some 2,3-Disubstituted Pyrazine Monoxides

The reactions of 2,3-dimethyl- (4), 2,3-diphenyl- (6), and 2-methyl-3-phenyl-pyrazine monoxides (8 and 9) with phosphoryl chloride and acetic anhydride resulted in giving monochloro- and monoacetoxy-pyrazines in almost all cases.However, the reaction of 6 with acetic anhydride afforded exceptionally a diacetoxydihydropyrazine.These products were converted further to hydroxy or dichloro derivatives.