74442-95-8

Basic information

• Product Name: Ethyl 3-Carbamoyl-4-hydroxybenzoate
• Synonyms: Ethyl 3-Carbamoyl-4-hydroxybenzoate
• CAS NO: 74442-95-8
• Molecular Weight: 209.202
• Mol File: 74442-95-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethyl 3-Carbamoyl-4-hydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-Carbamoyl-4-hydroxybenzoate(74442-95-8)
• EPA Substance Registry System: Ethyl 3-Carbamoyl-4-hydroxybenzoate(74442-95-8)

Safety Data

• Hazardous Substances Data: 74442-95-8(Hazardous Substances Data)

Upstream product

• 5977-14-0 acetoacetamido 
• 4869-46-9 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 

Downstream Products

• 76142-87-5 5-carboxysalicylamide 

Relevant articles and documents

Pyrimidine Derivatives and Related Compounds. 39. A Novel Cycloaromatization Reaction of 5-Formyl-1,3-dimethyluracil with Three-Carbon Nucleophiles. Synthesis of Substituted 4-Hydroxybenzoates

Treatment of 5-formyl-1,3-dimethyluracil (1) with α-substituted acetone derivatives (C-C-C type nucleophiles) such as acetylacetone, acetoacetamide, ethyl acetoacetate, and phenylacetone in basic media affords the corresponding 4-hydroxybenzoates (4).On the other hand, treatment of 1 with cyanoacetamide, a C-C-N type nucleophile, gives the nicotinate 8.A mechanism for this cycloaromatization was proposed on the basis of reaction of 5-formyl-1,3-dimethyluracil-d1 (6) with acetylacetone.