74442-97-0

Basic information

• Product Name: 3-(Ethoxycarbonyl)-4-hydroxy-N-methylbenzamide
• Synonyms: 3-(Ethoxycarbonyl)-4-hydroxy-N-methylbenzamide
• CAS NO: 74442-97-0
• Molecular Weight: 223.229
• Mol File: 74442-97-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(Ethoxycarbonyl)-4-hydroxy-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Ethoxycarbonyl)-4-hydroxy-N-methylbenzamide(74442-97-0)
• EPA Substance Registry System: 3-(Ethoxycarbonyl)-4-hydroxy-N-methylbenzamide(74442-97-0)

Safety Data

• Hazardous Substances Data: 74442-97-0(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 4869-46-9 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 

Relevant articles and documents

Heterocyclic transformations. Part 7. Unprecedented transformations of 1,3-dialkyl-5-formyluracils to 1,3-dialkyl-7-hydroxyquinazolines

1,3-Dialkyl-5-formyluracil reacts with ethyl acetoacetate, acetylacetone, benzoylacetone, acetoacetamide and acetoacetanilide under phase transfer catalytic conditions to provide exclusively the annulation products: 6-substituted-1,3-dialkyl-7-hydroxyquinazolines or/and also 4-hydroxybenzamide derivatives.Similar reaction with cyanoacetamide provides 6-cyano-7-hydroxy-1,3-dimethylpyridopyrimidine.The reaction mechanism prevailing in these reactions has been rationalized.