74457-80-0Relevant academic research and scientific papers
Benzoquinolizines having blood pressure lowering activity, and in some instances, anti-secretory activity
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, (2008/06/13)
The invention concerns benzoquinolizines of the general formula (I) STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein R1 and R2 which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy or halogen and R represents --CXNHR3 (where X is O, S or =NH and R3 is hydrogen or lower alkyl) or --(CH2)n R4 (where n is 0 or 1 and R4 is aryl). These compounds lower blood pressure. Some are also anti-ulcer agents. The compounds in which R1, R2 and R are as defined above, with the proviso that when R is phenyl, R1 and R2 are not both lower alkoxy, are novel.
