74470-79-4

Upstream product

• 4437-80-3 4,4-dimethyl-5-methylene-1,3-dioxolan-2-one 
• 95-76-1 m,p-dichloroaniline 
• 102-36-3 3,4-dichlorophenylisocyanate 
• 32496-69-8 2-methylbut-3-yn-2-yl (3,4-dichlorophenyl)carbamate 

Relevant academic research and scientific papers

Facial selectivity induced by N-aryl atropisomerism in benzonitrile oxide cycloadditions with 4-methylene-2-oxazolidinones

N-Aryl 4-methylene-2-oxazolidinones, prepared via the corresponding O-propargyl carbamates, underwent nitrile oxide cycloaddition with benzonitrile oxide to give 5-spiro isoxazoline adducts with complete regioselectivity. Steric hindrance by atropisomerism around the N-aryl bond induced facial selectivity in these cycloadditions.