74470-99-8Relevant academic research and scientific papers
Sila-Drugs, 16th Communication. Sila-Analogues of Nifedipine-Like Dialkyl 4-Aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates, I
Tacke, R.,Bentlage, A.,Towart, R.,Meyer, H.,Bossert, F.,et al.
, p. 494 - 501 (2007/10/02)
The nifedipine-like 1,4-dihydropyridines 10a and 11a as well as their sila-analogues 10b, 10c, and 11b were synthesized for the first time. 10a, 10b, 10c, 11a, 11b, and their precursors 8a, 8b, 9a, and 9b were characterized by their physical and chemical properties, and their structures confirmed by analyses, 1H NMR and mass spectroscopy.The antispasmodic, vasodilating, and antihypertensive properties of 10a, 10b, 10c, 11a, and 11b were compared. - Keywords: Sila-analogues of Nifedipine Derivatives, Syntheses, Pharmacological Activity
Sila-substituted 1,4-dihydropyridine derivatives and their medicinal use
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, (2008/06/13)
The invention provides sila-substituted 1,4-dihydropyridine derivatives useful as medicament which influence the circulation. Also included in the invention are methods for the procurement of said derivatives, compositions containing said derivatives and
