74476-72-5

Upstream product

• 838-57-3 ethyl 4-nitrobenzoylacetate 

Downstream Products

• 94464-32-1 2-benzoyloxymethyl-4-(4-nitro-phenyl)-thiazole-5-carboxylic acid ethyl ester 
• 68301-50-8 ethyl 2-amino-4-(4-nitrophenyl)thiazole-5-carboxylate 
• 475585-16-1 diethyl 2-amino-5-(4-nitrophenyl)furan-3,4-dicarboxylate 
• 91135-95-4 2-hydroxymethyl-4-(4-nitro-phenyl)-thiazole-5-carboxylic acid 
• 91634-89-8 2-formyl-4-(4-nitro-phenyl)-thiazole-5-carboxylic acid 
• 74476-62-3 ethyl 2-chloro-4-p-nitrophenyl-5-thiazolecarboxylate 
• 475585-13-8 4-hydroxy-6-(4-nitrophenyl)furo[2,3-d]pyrimidine-5-carboxylic acid 
• 475585-12-7 6-(4-nitrophenyl)furo[2,3-d]pyrimidin-4-ol 
• 475585-11-6 4-chloro-6-(4-nitrophenyl)furo[2,3-d]pyrimidine 
• 475585-10-5 N-(4-chloro-2-fluorophenyl)-6-(4-nitrophenyl)furo[2,3-d]pyrimidin-4-amine 
• 475585-18-3 2-methoxy-5-{[6-(4-nitrophenyl)furo[2,3-d]pyrimidin-4-yl]amino}phenol 
• 475585-20-7 N-(3-nitrophenyl)-6-(4-nitrophenyl)furo[2,3-d]pyrimidin-4-amine 
• 475585-19-4 2-methyl-5-{[6-(4-nitrophenyl)furo[2,3-d]pyrimidin-4-yl]amino}phenol 
• 475585-17-2 N-(3-chlorophenyl)-6-(4-nitrophenyl)furo[2,3-d]pyrimidin-4-amine 

Relevant academic research and scientific papers

Furo[2,3-d]pyrimidines and Oxazolo[5,4-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases (RTK)

Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.