74492-20-9

Upstream product

• 82255-42-3 2,2-difluoro-1-phenyl-ethanol 
• 395-01-7 2,2-difluoro-1-phenylethanone 

Relevant academic research and scientific papers

gem-Difluorination of Alkenyl N-methyliminodiacetyl Boronates: Synthesis of α- and β-Difluorinated Alkylborons

Organofluorine compounds are widely used in pharmaceutical, agrochemical, and materials sciences. The syntheses and applications of fluorinated organoborons facilitate the rapid and modular assemblies of fluorine-containing molecules because of the versatility of C?B bonds in diverse chemical transformations. Reported herein is a migratory geminal difluorination of aryl-substituted alkenyl N-methyliminodiacetyl (MIDA) boronates using commercially available Py?HF as the fluorine source and hyperiodine as the oxidant. The protocol offers facile access to α- and β-difluorinated alkylboron compounds, both of which have previously been challenging to prepare. Mild reaction conditions, broad substrate scope, good functional-group tolerance, and moderate to good yields were observed. The utility of these products is demonstrated by further transformations of the C?B bond into other valuable functional groups.

A kind of the geminally alkyl boric acid ester compound and its preparation method and application (by machine translation)

The invention discloses a geminally alkyl boric acid ester compound and its preparation method and application. The structure of the compound of formula (I) as shown; wherein R is or ; R1 Is phenyl, substituted phenyl, biphenyl or thiophene; R2 Hydrogen, halogen, hydroxy, C1 - 4 Alkyl, C1 - 4 Alkoxy, phenyl, substituted phenyl; R3 Is phenyl or substituted phenyl. The compound of the invention the structure is stable, at the same time with two alkyl and boric acid ester, can be used as a raw material, more simple, convenient, and rapid preparation in a pharmaceutically has high-value of the compound. In addition, the preparation of the compounds is simple, the preparation method of the reaction substrate has wide applicability, can be prepared a plurality of the geminally alkyl boric acid ester compound; at the same time, the method of the mild reaction conditions, without metal reagent, does not need high temperature or high pressure, does not need to be acid or alkali additive, and the reaction time is short, simple and convenient operation, after treatment is simple, is a high-efficient synthetic geminally halothane base boron ester compounds. (by machine translation)

MECHANISMS OF FREE-RADICAL REACTIONS. XX. REACTIVITY IN THE FREE-RADICAL HALOGENATION REACTIONS OF ARYLFLUOROALKANES

The free-radical chlorination and bromination of meta- and para-substituted benzyl fluorides and 1,1-difluoro-2-phenylethane and also the chlorination of 1-fluoro-2-arylethanes by phenylchloroiodonium chloride and the bromination of meta- and para-substituted benzyl bromides were studied by the method of competing reactions.In all cases a good correlation is observed between log krel and the Brown ?+ constants.In cases where change in the reactivity in the transition from one reaction series to another is due mainly to the polar effect of the substituent whilethe selectivity is measured in relation to the polar effect direct relationships are observed between the reactivity and the selectivity.