74495-69-5Relevant articles and documents
DEUTERATED PIPERAZINE DERIVATIVES AS ANTI-ANGINAL COMPOUNDS
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Page/Page column 23-24, (2008/12/08)
This invention relates to novel compounds of formula A that partially inhibit fatty acid oxidation and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel compounds that are derivatives of ranolazine. This invention also provides compositions comprising one or more compound of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by partial fatty acid oxidation inhibitors, such as ranolazine. (Formula A), wherein at least one of Y or R comprises a deuterium atom.
SUBSTITUTED PIPERAZINES
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Page/Page column 32, (2009/01/24)
Disclosed herein are substituted piperazine late Na+ channel modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
Preparation of synthetic lignins with superior NMR characteristics via isotopically labeled monolignols
Ralph, John,Zhang, Yingsheng,Ede, Richard M.
, p. 2609 - 2613 (2007/10/03)
Synthetic lignins are particularly valuable for studying aspects of lignification, plant cell wall cross-linking, and lignin structure. If they are not too highly polymeric, they are soluble in normal lignin solvents and amenable to solution-state NMR studies. However, in the application of inverse-detected correlation experiments, particularly the popular HMQC and HMBC experiments, the spectra have annoying T1-noise ridges. These artifacts make it difficult to locate correlation peaks that are near the methoxy signal in the proton dimension. One solution is to use gradient-enhanced NMR but that requires additional hardware that is not yet ubiquitous. An alternative is to produce monolignols in which the atoms of the methoxy group are NMR-invisible. We have accomplished this by preparing coniferyl and sinapyl alcohols using 13C-depleted deuterated methyl iodide (12C2H3I). The methods, which incorporate steps simpler than have been used previously for labeled monolignols, are sufficiently low cost and straight-forward that these monomers can be utilized for any synthetic lignins destined for NMR studies. The NMR spectra of lignins derived from these 'methoxy-less' monomers are markedly superior to their normal-monomer counterparts. Several popular NMR experiments are illustrated for synthetic lignins derived from normal vs. isotopically labeled coniferyl alcohol, along with some useful experiments that have not been seen in lignin-related publications to date.