745-62-0 Usage
Uses
1. Used in Aquatic Biology:
PROSTAGLANDIN F1ALPHA is used as a priming pheromone for male Atlantic salmon to stimulate their reproductive behavior.
2. Used in Pharmaceutical Research:
PROSTAGLANDIN F1ALPHA is used as a smooth muscle relaxant and a stable metabolite of prostacyclin (PGI2) for studying its effects on human respiratory smooth muscle contractions.
3. Used in Mass Spectrometry and Related Applications:
PROSTAGLANDIN F1ALPHA is used as a quantitative grade standard, specifically prepared for mass spectrometry, to ensure accurate and reproducible results in related applications. The PGF1α MaxSpec standard guarantees identity, purity, stability, and concentration specifications, making it suitable for precise measurements and calibration standards.
Biochem/physiol Actions
PGs mediate vasodilation and vasoconstriction.
Check Digit Verification of cas no
The CAS Registry Mumber 745-62-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,4 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 745-62:
(5*7)+(4*4)+(3*5)+(2*6)+(1*2)=80
80 % 10 = 0
So 745-62-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
745-62-0Relevant articles and documents
Regio- and Stereoselectivity of the Reaction between Cyanocuprates and Cyclopentene Epoxides. Application to the Total Synthesis of Prostaglandins
Marino, Joseph P.,Pradilla, Roberto F. de la,Laborde, Edgardo
, p. 4898 - 4913 (2007/10/02)
A systematic study of the reaction between cyclopentene epoxides and alkyl-, alkenyl-, and arylcyanocuprates is described.Alkylcyanocuprates react with complete regio- and stereoselectivity to provide trans-4-alkylcyclopent-2-enols in excellent yields.Vin
Stereocontrolled Synthesis of Prostaglandins from Cyclopentadiene Monoepoxide
Marino, Joseph P.,Pradilla, Roberto Fernandez de la,Laborde, Edgardo
, p. 5279 - 5280 (2007/10/02)
Two complementary syntheses of prostaglandins from the same key intermediate 3, available in four steps from cyclopentadiene monoepoxide, are described.In one approach, a saturated α-chain is introduced via a 1,4-addition of an appropriately functionalized cyanocuprate reagent onto silyl enol ether 3.The resulting prostanoid compound was converted into the bronchodilator 1-decarboxy-1-hydroxymethyl PGE1, PGE1, and PGF1α.The second approach involves the transformation of silyl enol ether 3 into the known prostanoid precursor 11 via selective addition of carbethoxycarbene and subsequent fluoride-induced ring opening of the resulting (silyloxy)cyclopropane carboxylate ester.
