7450-57-9

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Amino-4-hydroxybenzoic acid is used as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with diverse therapeutic applications.
Used in Dye Production:
3-AMINO-4-HYDROXYBENZOIC ACID is utilized as an intermediate in the production of various dyes, playing a crucial role in the coloration and staining processes across different industries.
Used as a Substitute in Laminated Products Manufacturing:
3-Amino-4-hydroxybenzoic acid serves as a substitute for urea-formaldehyde resins in the manufacture of laminated products, offering an alternative material with potential environmental and performance benefits.
Used in Antiviral Drug Development:
In the field of medicine, 3-Amino-4-hydroxybenzoic acid is explored for its potential in the development of antiviral drugs, aiming to combat viral infections and diseases.
Used in Anticancer Drug Development:
3-AMINO-4-HYDROXYBENZOIC ACID is also considered in the development of anticancer drugs, with the potential to contribute to novel therapeutic strategies against cancer.

InChI:InChI=1/C7H9N3O2/c8-5-3-4(7(12)10-9)1-2-6(5)11/h1-3,11H,8-9H2,(H,10,12)

Upstream product

• 536-25-4 methyl 3-amino-4-hydroxybenzoate 

Downstream Products

• 807628-31-5 C₃₁H₃₄N₆O₆Si 
• 192862-31-0 (2Z,4E)-5-{(S)-4-[(3-Azido-4-hydroxy-benzoyl)-hydrazono]-1-hydroxy-2,6,6-trimethyl-cyclohex-2-enyl}-3-methyl-penta-2,4-dienoic acid 

Relevant academic research and scientific papers

Novel self-dyed wholly aromatic polyamide-hydrazides covalently bonded with azo groups in their main chains: 1. structure-property relationships

Twelve novel intrinsically colored wholly aromatic azopolyamide-hydrazides containing various proportions of para- and meta-phenylene units were successfully synthesized by a low temperature (-10 °C) solution polycondensation reaction of either 4-Amino-3-hydroxybenzhydrazide (4A3HBH) or 3-Amino-4-hydroxybenzhydrazide (3A4HBH) with an equimolar amount of either 4,4'-Azodibenzoyl chloride (4,4'ADBC), 3,3'-Azodibenzoyl chloride (3,3'ADBC), or mixtures of various molar ratios of 4,4'ADBC and 3,3'ADBC in anhydrous N,N-dimethyl acetamide (DMAc) containing 3% (wt/v) LiCl as a solvent. The structures of the polymers were proven by elemental analysis, FTIR, 1H- and 13C-NMR spectroscopy. The polymers' properties were strongly affected by their various structures. The intrinsic viscosities of the polymers were ranged from 0.7 to 4.75 dL g-1 and increased with the para-phenylene units content. The polymers are partially soluble in DMAc, dimethyl formamide (DMF) and N-methyl-2-pyrrolidone (NMP). Their solubility increases with the introduction of meta-phenylene moieties into the polymer chains. The polymers exhibit a great affinity for water sorption. Their hydrophilicity increases as a function of the content of meta-phenylene rings incorporated into the polymer. Mechanical properties of the polymer films are improved markedly by substitution of para-phenylene units for meta-phenylene units. The completely para-oriented type polymer has the best thermal and thermo-oxidative stability relative to those of the other polymers.

Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides

A series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC50 values lower than standard drugs. Brief SAR analysis revealed that substitution is important to the activity. Nitrothiophene analogues were more potent than the nitrofuran ones. This was attributed to the ability of sulfur atoms in accommodating electrons from nitro group, which facilitate its reduction and therefore the formation of free radicals lethal to parasites.

Glucagon antagonists/inverse agonists

Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.

Amino-benzoic acids and derivatives, and methods of use

The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Methods for glycosylation inhibition using amino-benzoic acids and derivatives

The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.