745066-40-4

Upstream product

• 86623-74-7 C₁₀H₁₂O₂ 
• 100-46-9 benzylamine 
• 7329-08-0 3a,4,5,6,7,7a-hexahydro-4,7-methano-indene-5,6-diol 

Downstream Products

• 745066-36-8 10-benzyl-4,10-diaza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene 
• 833458-81-4 C₁₇H₂₁NO₂ 
• 833458-82-5 3-(phenylmethyl)-3-azabicyclo[3.2.1]octane-6,7-dicarbaldehyde bis (O-methyloxime) 
• 745066-39-1 9-benzyl-9-aza-tricyclo[5.3.1.02,6]undecane-3,4-diol 

Relevant academic research and scientific papers

Pyridine analogs of (-)-cytisine and varenicline: cholinergic receptor probes

A series of bicyclic pyridine containing alkaloids related to (-)-cytisine and varenicline are described. Synthetic access via regioisomeric metalation of alkoxy- and halo-pyridines gains entry to all four isomeric [3.3.1]-bicyclic targets. Regioselective

Heteroaryl fused azapolycyclic compounds

The present invention provides a compound having the structure of formula I: wherein R1 is hydrogen, (C1-C6) alkyl, unconjugated (C3-C6) alkenyl, benzyl, YC(═O)(C1-C6) alkyl or —CH2CH2—O—(C1-C4) alkyl; X is CH2 or CH2CH2; Y is (C2-C6) alkylene; Z is (CH2)m, CF2, or C(═O), where m is 0, 1 or 2; R2 and R3 are selected independently from hydrogen, halogen, —(C1-C6) alkyl optionally substituted with from 1 to 7 halogen atoms, and —O(C1-C6) alkyl optionally substituted with from 1 to 7 halogen atoms, or R2 and R3 each together with the atom to which it is connected independently form C(═O), S→O, S(═O)2, or N→O; and is a 5- to 7-membered monocyclic heteroaryl group selected from pyridinyl, pyridone, pyridazinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, cinnolinyl, triazinyl, oxadiazolyl, thiadiazolyl and furazanyl groups.

ANTIPARASITIC TERPENE ALKALOIDS

The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation. More particularly, the present invention relates to derivatives of the terpene alkaloid (1S,2R,4aS,5R,8R,8aR)-2-(acetyloxy)-8a-hydroxy-3,8-dimethyl-5-(1-methylethenyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate. Pharmaceutical compositions comprising the same are also disclosed.