745071-81-2

Upstream product

• 95124-07-5 dimethyl (prop-2-yn-1-yl)malonate 
• 20451-53-0 Phenyl vinyl sulfoxide 
• 745072-09-7 2-(2-benzenesulfinylethyl)-2-prop-2-ynylmalonic acid dimethyl ester 

Relevant academic research and scientific papers

Preparation of 5-membered rings via radical addition-translocation- cyclization (RATC) processes mediated by diethyl thiophosphites

A practical method for the formation of thiophosphonates bearing functionalized monocyclic, fused bicyclic and spirocyclic residues is presented. The procedure requires the easily available terminal alkynes as starting materials as well as commercially an

Thiophenol-mediated 1,5-hydrogen atom abstraction: Easy access to mono- and bicyclic compounds

A thiophenol-mediated method for cyclization of alkynes is described. The reaction cascade involves the intermolecular addition of a phenylthiyl radical to a terminal triple bond generating an alkenyl radical, followed by a 1,5-hydrogen atom transfer and a 5-exo-trig radical cyclization. This very efficient tin-free procedure allows one to prepare highly functionalized cyclopentane derivatives as well as fused bicyclic and spirocyclic compounds from easily available precursors. During this cyclization process, a phenylthio moiety is incorporated into the final cyclized products. This functionalization is particularly attractive for further transformation of the products.

Thiophenol-mediated hydrogen atom abstraction: An efficient tin-free procedure for the preparation of cyclopentane derivatives

(Matrix Presented) An efficient procedure for running a cascade reaction involving 1,5-abstraction of a hydrogen atom followed by a radical cyclization is reported. Alkenyl radicals are generated from easily available terminal alkynes and thiophenol. This procedure eliminates the need of using the toxic tributyltin hydride and gives a greater amount of radical translocation products.