745074-64-0

Upstream product

• 119008-52-5 (S,S)-2,5-bis(methylsulfonyloxy)hexane 
• 104-53-0 3-phenyl-propionaldehyde 
• 834880-35-2 (2R,5R)-1-amino-2,5-dimethylpyrrolidine 

Downstream Products

• 1048332-50-8 2-(benzyloxy)-N-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-N-3-(3-phenylprop-1-enyl)acetamide 
• 1048332-77-9 cis-(3R,4S)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-(2-phenylethyl)azetidin-2-one 

Relevant academic research and scientific papers

Stereoselective, temperature-dependent [2+2] cycloaddition of N,N-dialkylhydrazones to N-benzyl-N-(benzyloxycarbonyl)aminoketene

The Staudinger-like [2+2] cycloaddition of aliphatic hydrazones derived from (2R,5R)-1-amino-2,5-dimethylpyrrolidine to N-benzyl-N-(benzyloxycarbonyl) aminoketene takes place to afford the corresponding β-lactams in good yields when iPr2EtN is

Studies on stereoselective [2+2] cycloadditions between N,N-dialkylhydrazones and ketenes

Staudinger-like cycloadditions between chiral, non-racemic N,N-dialkylhydrazones 1 and functionalized ketenes constitute an efficient methodology for the stereoselective construction of the β-lactam ring. The potential for fine tuning of the dialkylamino