7452-87-1Relevant academic research and scientific papers
Application of gastrodia elata bl derived derivatives to preparation of medicine for treating Inflammatory Bowel disease (IBD)
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, (2021/01/20)
The invention discloses compounds as shown in general formulas (I) and (II) and application of pharmaceutically acceptable salt thereof to preparation of a medicine for treating the Inflammatory Boweldisease (IBD), and discloses a preparation method of the compounds.
Thioether type compound as well as synthesis method and application thereof
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Paragraph 0044-0047; 0048-0051; 0052-0055, (2018/09/13)
The invention provides a thioether type compound and also relates to a synthesis method of the thioether type compound and application of the thioether type compound. A chemical structure of the thioether type compound enables the thioether type compound to have a relatively high melting point and be not easily sublimated, so that the thioether type compound has relatively good thermal stability;the thioether type compound has an excellent anti-oxidization capability and has no toxic and side effects, so that the thioether type compound has relatively high utilization safety; secondly, a target compound is synthesized by the synthesis method of the thioether type compound, provided by the invention, by adopting one-step reaction; visibly, the synthesis method is simple to operate, moderate in technological conditions, green and environmentally friendly, and is very suitable for large-scale industrial production. A series of experiments prove that the thioether type compound has an obvious inhibition effect on oxidization of various foods and an anti-oxidization effect of the compound has a certain dose-effect relationship with the concentration of the compound; therefore, the thioether type compound provided by the invention has a wide application prospect and a good market potential.
Identification and Organoleptic Contribution of Vanillylthiol in Wines
Floch, Morgan,Shinkaruk, Svitlana,Darriet, Philippe,Pons, Alexandre
, p. 1318 - 1325 (2016/02/27)
Vanillylthiol, a chemical compound reminiscent of clove and smoke, has been identified for the first time in young red and dry white wines. The chemical structure of this new aroma was confirmed by original chemical synthesis. Vanillylthiol was prepared by a two-step procedure from vanillin. The conversion of vanillin to divanillyl disulfide was easily achieved by treatment with an inorganic sulfur-donor reagent. Reduction of the disulfide gave the target thiol in good yield. The quantification of vanillylthiol in wine was performed by nonspecific liquid/liquid extraction (CH2Cl2), separation of the volatile compounds using gas chromatography, and specific detection using tandem mass spectrometry (triple quadrupole). Vanillylthiol was found particularly in young wines aged in new oak barrels. These wines contained between a few 50 ng/L to more than 8300 ng/L. The highest levels were found in red wines aged 12 months in new oak barrels. Given its perception threshold in a wine model solution (3.8 μg/L), vanillylthiol may contribute to the spicy, clove-like flavor of red wines aged in oak barrels.
