74533-11-2Relevant articles and documents
Chemical synthesis method of (R)-2-phenoxypropionic acid
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Paragraph 0020; 0036; 0046; 0047; 0048, (2019/01/14)
The invention discloses a chemical synthesis method of (R)-2-phenoxypropionic acid. The chemical synthesis method comprises the following steps: performing diazotization and chlorination on L-alanineserving as a starting material to obtain (S)-2-chloropro
Synthesizing method of L-2-sodium chloropropionate
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Paragraph 0043-0049, (2017/04/03)
The invention discloses a synthesizing method of L-2-sodium chloropropionate.The synthesizing method comprises the steps that hydrochloric acid is directly sucked or pumped into a reaction kettle, and L-2-aminopropionic acid solids are put into the reaction kettle; the temperature is lowered to 0 DEG C or below through an ice bath, prepared sodium nitrite is added in batches, stirring is stopped after reacting is finished, and standing under heat preservation is performed for 2-3 hours; suction filtration is performed, L-2-chloropropionic acid filtrate obtained through suction filtration is contained in a separating funnel oscillator to be extracted, obtained extracting solutions are merged after layering under standing is performed, alkali liquid is added into the merged extracting solution for a neutralization reaction, layering under standing is performed, an obtained oil layer is dichloromethane solvent, and a water layer is an aqueous solution of L-2-sodium chloropropionate.According to the synthesizing method of L-2-sodium chloropropionate, the alkali liquid is directly added into the dichloromethane extracting solution of L-2-chloropropionic acid for neutralization, distilling is replaced with layering, the whole dichloromethane distilling and recycling process is omitted, and therefore not only is the efficiency greatly improved, but also energy consumption is greatly reduced.