7455-91-6Relevant articles and documents
Synthesis of some new quinazolin-4(3H)-one derivatives and evaluation of their anticonvulsant activity
Boshta, Nader M.,El-Essawy, Farag A.,Ammar, Ramy M.,Ismail, Abd El-Hamid,Wahba, Nancy E.
, p. 2031 - 2042 (2016/10/21)
We reported the synthesis of a novel series of quinazolin-4(3H)-one derivatives bearing oxadiazole, thiadiazole, and other moieties in the 3-position of the quinazolinone nucleus using appropriate synthetic route. The compounds were evaluated for their anticonvulsant activity using picrotoxin model, GABA-A receptor antagonist. Five compounds showed significantly prolonged times for convulsions compared with the standard drug phenobarbital. Graphical abstract: [Figure not available: see fulltext.]