74572-05-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
(R)-3-Ethylmorpholine is used as a building block for the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides due to its versatile chemical structure and reactivity.
Used in Rubber Chemicals Production:
(R)-3-Ethylmorpholine is used as a key component in the production of rubber chemicals, enhancing the properties of rubber materials and expanding their applications in various industries.
Used in Surfactant Manufacturing:
(R)-3-Ethylmorpholine is utilized in the manufacturing of surfactants, which are essential in the formulation of detergents, cleaners, and other products that require emulsification or dispersion properties.
Used in Corrosion Inhibitor Formulation:
(R)-3-Ethylmorpholine is used as a component in corrosion inhibitors, helping to protect metal surfaces from corrosion and extending the lifespan of materials used in various industrial applications.

InChI:InChI=1/C6H13NO/c1-2-6-5-8-4-3-7-6/h6-7H,2-5H2,1H3/t6-/m1/s1

Upstream product

• 1007113-30-5 (5R)-5-ethyl-3-morpholinone 
• 466695-50-1 2-chloro-N-[(2R)-1-hydroxybutan-2-yl]acetamide 
• 74572-06-8 R-(-)-N-(β-hydroxyethyl)-2-amino-1-butanol 

Downstream Products

• 1258394-20-5 8-benzyl-3-[(3R)-3-ethylmorpholin-4-yl]-6,7,8,9-tetrahydropyrazino[2,3-f][1,4]oxazepine 
• 117607-19-9 (R)-2-<1-<2-(3-ethyl-4-morpholinyl)phenyl>ethylidene>propanedinitrile 
• 117607-18-8 (R)-2-<<2-(3-ethyl-4-morpholinyl)phenyl>methylene>propanedinitrile 
• 211987-82-5 (R)-(-)-4-amino-3-ethylmorpholine 
• 117607-14-4 (R)-2-(3-ethyl-4-morpholinyl)benzaldehyde 
• 117607-16-6 (R)-1-<2-(3-ethyl-4-morpholinyl)phenyl>ethanone 

Relevant academic research and scientific papers

A concise and efficient synthesis of substituted morpholines

A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.

CHEMICAL COMPOUNDS

The invention is directed to to substituted indazole derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1 - R6 and X are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of disorders characterized by constitutively activated ACG kinases such as cancer and more specifically leukemia and cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Enantioselective syntheses of α-phenylalkanamines via intermediate addition of Grignard reagents to chiral hydrazones derived from (R)-(-)-2- aminobutan-1-ol

The hydrazine (R)-(-)-28 was obtained in four steps from 2-aminobutan- 1-ol (R)-(-)-11, and reacted with benzaldehyde to give the hydrazone (R)-(- )-29. Nucleophilic addition of various alkyl Grignard reagents to the latter yielded the corresponding trisubstituted hydrazines (R,R)-30a-g in 70-89% yields and having d.e.s=100% (1H and 13C NMR). Catalytic hydrogenolysis of these hydrazines afforded the corresponding (R)(+)-α-phenylalkanamines (R)- (+)-31a-g having e.e.s=90-92% (chiral GPC).

SYNTHESIS AND ABSOLUTE CONFIGURATION OF SUBSTITUTED MORPHOLINES

We studied methods of stereospecific synthesis that enabled us to obtain variously substituted morpholinic compounds and to determine their absolute configuration.From a study of the chiroptical properties of synthetic N-(2-pyridyl-N-oxide) derivatives of optically active morpholines, it was possible to correlate the sign of the Cotton effect with the absolute configuration.This correlation agrees with that previously established for derivatives of the piperidine type.By evaluating the various contributions to the Cotton effect of substituents in positions 2 and 3, we established the absolute configuration of bicyclic compounds condensed in the two positions mentioned above.