74572-05-7

Basic information

• Product Name: (R)-3-Ethylmorpholine
• Synonyms: (R)-3-Ethylmorpholine;(3R)-3-Ethylmorpholine;(R)-3-Ethyl-morpholine HCl
• CAS NO: 74572-05-7
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17
• Mol File: 74572-05-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 160.6 °C at 760 mmHg
• Flash Point: 54.2 °C
• Appearance: /
• Density: 0.878g/cm³
• Vapor Pressure: 2.36mmHg at 25°C
• Refractive Index: 1.413
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-3-Ethylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Ethylmorpholine(74572-05-7)
• EPA Substance Registry System: (R)-3-Ethylmorpholine(74572-05-7)

Safety Data

• Hazardous Substances Data: 74572-05-7(Hazardous Substances Data)

Usage

General Description

(R)-3-Ethylmorpholine is a chemical compound with the formula C6H13NO. It is an organic compound with a heterocyclic ring structure, containing an ethyl group attached to a morpholine ring. (R)-3-Ethylmorpholine is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of rubber chemicals, surfactants, and corrosion inhibitors. (R)-3-Ethylmorpholine is a versatile compound that has various industrial applications due to its unique chemical properties and reactivity, making it an important intermediate in the manufacturing of a wide range of products.

InChI:InChI=1/C6H13NO/c1-2-6-5-8-4-3-7-6/h6-7H,2-5H2,1H3/t6-/m1/s1

Upstream product

• 466695-50-1 2-chloro-N-[(2R)-1-hydroxybutan-2-yl]acetamide 
• 74572-06-8 R-(-)-N-(β-hydroxyethyl)-2-amino-1-butanol 
• 1007113-30-5 (5R)-5-ethyl-3-morpholinone 

Downstream Products

• 1258394-20-5 8-benzyl-3-[(3R)-3-ethylmorpholin-4-yl]-6,7,8,9-tetrahydropyrazino[2,3-f][1,4]oxazepine 
• 117607-19-9 (R)-2-<1-<2-(3-ethyl-4-morpholinyl)phenyl>ethylidene>propanedinitrile 
• 117607-18-8 (R)-2-<<2-(3-ethyl-4-morpholinyl)phenyl>methylene>propanedinitrile 
• 211987-82-5 (R)-(-)-4-amino-3-ethylmorpholine 
• 117607-14-4 (R)-2-(3-ethyl-4-morpholinyl)benzaldehyde 
• 117607-16-6 (R)-1-<2-(3-ethyl-4-morpholinyl)phenyl>ethanone 

Relevant articles and documents

A concise and efficient synthesis of substituted morpholines

A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.

Enantioselective syntheses of α-phenylalkanamines via intermediate addition of Grignard reagents to chiral hydrazones derived from (R)-(-)-2- aminobutan-1-ol

The hydrazine (R)-(-)-28 was obtained in four steps from 2-aminobutan- 1-ol (R)-(-)-11, and reacted with benzaldehyde to give the hydrazone (R)-(- )-29. Nucleophilic addition of various alkyl Grignard reagents to the latter yielded the corresponding trisubstituted hydrazines (R,R)-30a-g in 70-89% yields and having d.e.s=100% (1H and 13C NMR). Catalytic hydrogenolysis of these hydrazines afforded the corresponding (R)(+)-α-phenylalkanamines (R)- (+)-31a-g having e.e.s=90-92% (chiral GPC).