74572-29-5

Basic information

• Product Name: 5-CHLOROISOINDOLIN-1-ONE
• Synonyms: 5-CHLOROISOINDOLIN-1-ONE;5-Chloro-2,3-dihydroisoindol-1-one;1H-Isoindol-1-one, 5-chloro-2,3-dihydro-;5-Chloro-1-isoindolinone;5-Chloro-2,3-dihydro-1H-isoindol-1-one
• CAS NO: 74572-29-5
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.59
• Mol File: 74572-29-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 436.5 °C at 760 mmHg
• Flash Point: 217.8 °C
• Appearance: /
• Density: 1.362±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 8.03E-08mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-CHLOROISOINDOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROISOINDOLIN-1-ONE(74572-29-5)
• EPA Substance Registry System: 5-CHLOROISOINDOLIN-1-ONE(74572-29-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 74572-29-5(Hazardous Substances Data)

Usage

General Description

5-Chloroisoindolin-1-one is a complex organic compound belonging to the class of substances known as isoindolones. Its structure features a unique combination of an isoindoline ring (which includes a six-membered ring bonded to a nitrogen atom) with a ketone group (a carbon atom double-bonded to an oxygen atom), with an added chlorine atom. The compound has potential applications in the field of medicinal and pharmaceutical chemistry due to its versatile chemical structure that may react with or modify other biochemical compounds. However, its specific properties, interactions, and potential uses are still subject to ongoing scientific research.

InChI:InChI=1/C8H6ClNO/c9-6-1-2-7-5(3-6)4-10-8(7)11/h1-3H,4H2,(H,10,11)

Upstream product

• 201230-82-2 carbon monoxide 
• 4152-90-3 m-chlorobenzylamine 
• 145908-29-8 methyl 2-(bromomethyl)-4-chlorobenzoate 
• 7499-07-2 4-chloro-2-methylbenzoic acid 

Downstream Products

• 1440519-61-8 5-chloro-2-(4-methoxybenzyl)-2,3-dihydroisoindol-1-one 
• 1263311-28-9 C₁₈H₁₆ClNO₃ 

Relevant articles and documents

Br?nsted Acid Catalyzed Dearomatization by Intramolecular Hydroalkoxylation/Claisen Rearrangement: Diastereo- and Enantioselective Synthesis of Spirolactams

Described herein is a novel Br?nsted acid catalyzed intramolecular hydroalkoxylation/Claisen rearrangement, allowing the practical and atom-economic synthesis of a range of valuable spirolactams from readily available ynamides in generally good to excellent yields with excellent diastereoselectivities and broad substrate scope. Importantly, an unexpected dearomatization of nonactivated arenes and heteroaromatic compounds is involved in this tandem sequence. Moreover, an asymmetric version of this tandem cyclization was also achieved by efficient kinetic resolution by chiral phosphoric acid catalysis. In addition, the [3,3]-rearrangement is shown to be kinetically preferred over the related [1,3]-rearrangement by theoretical calculations.

HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention related to novel heterocyclic amide compounds of Formula 1: as disclosed herein or a pharmaceutically accept able salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosedare compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease