74572-29-5

Usage

Uses

Used in Medicinal Chemistry:
5-Chloroisoindolin-1-one is used as a building block for the synthesis of various pharmaceutical compounds due to its reactive chemical structure. Its ability to form new bonds and interact with other molecules makes it a valuable component in the development of new drugs.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-Chloroisoindolin-1-one is used as a research tool to explore its potential interactions with biological systems. Its unique structure may lead to the discovery of new therapeutic agents or the improvement of existing ones, contributing to advancements in medicine.
Used in Chemical Synthesis:
5-Chloroisoindolin-1-one is used as a key intermediate in the synthesis of complex organic molecules. Its versatility in forming different types of chemical bonds makes it an essential component in the creation of novel compounds with potential applications in various industries, including materials science and specialty chemicals.
Used in Drug Development:
5-Chloroisoindolin-1-one is used as a potential candidate for drug development, as its structure may offer new avenues for targeting specific biological pathways or receptors. Ongoing research aims to understand its interactions with biological systems and how it can be harnessed to create effective treatments for various diseases.
Used in Material Science:
In the field of material science, 5-Chloroisoindolin-1-one is used as a component in the development of new materials with unique properties. Its ability to form stable bonds with other molecules may contribute to the creation of advanced materials with applications in electronics, coatings, and other industries.

InChI:InChI=1/C8H6ClNO/c9-6-1-2-7-5(3-6)4-10-8(7)11/h1-3H,4H2,(H,10,11)

Upstream product

• 201230-82-2 carbon monoxide 
• 4152-90-3 m-chlorobenzylamine 
• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 145908-29-8 methyl 2-(bromomethyl)-4-chlorobenzoate 

Downstream Products

• 1263311-28-9 C₁₈H₁₆ClNO₃ 
• 1440519-61-8 5-chloro-2-(4-methoxybenzyl)-2,3-dihydroisoindol-1-one 

Relevant academic research and scientific papers

Br?nsted Acid Catalyzed Dearomatization by Intramolecular Hydroalkoxylation/Claisen Rearrangement: Diastereo- and Enantioselective Synthesis of Spirolactams

Described herein is a novel Br?nsted acid catalyzed intramolecular hydroalkoxylation/Claisen rearrangement, allowing the practical and atom-economic synthesis of a range of valuable spirolactams from readily available ynamides in generally good to excellent yields with excellent diastereoselectivities and broad substrate scope. Importantly, an unexpected dearomatization of nonactivated arenes and heteroaromatic compounds is involved in this tandem sequence. Moreover, an asymmetric version of this tandem cyclization was also achieved by efficient kinetic resolution by chiral phosphoric acid catalysis. In addition, the [3,3]-rearrangement is shown to be kinetically preferred over the related [1,3]-rearrangement by theoretical calculations.

Palladium-Catalyzed Direct C-H Carbonylation of Free Primary Benzylamines: A Synthesis of Benzolactams

A protocol for palladium-catalyzed C-H carbonylation of readily available free primary benzylamines using NH2 as the chelating group under an atmospheric pressure of CO has been achieved, providing a general, atom- and step-economic approach to

HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention related to novel heterocyclic amide compounds of Formula 1: as disclosed herein or a pharmaceutically accept able salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosedare compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease