74578-38-4 Usage
General Description
The "1-UFT protocol" is a combination chemotherapy regimen consisting of three key drug components: tegafur, uracil, and leucovorin. Tegafur is a prodrug of 5-fluorouracil (5-FU), a potent anticancer agent that inhibits the growth of cancer cells by interfering with their DNA synthesis. Uracil is an inhibitor of dihydropyrimidine dehydrogenase, an enzyme responsible for inactivating 5-FU, thereby enhancing the effect of tegafur. Leucovorin, also known as folinic acid, is a derivative of folic acid that potentiates the action of 5-FU by increasing its incorporation into DNA and RNA, leading to enhanced cytotoxicity. This combination regimen is commonly used in the treatment of various solid tumors, such as colorectal, gastric, and breast cancers, and has demonstrated efficacy and tolerability in clinical trials.
Check Digit Verification of cas no
The CAS Registry Mumber 74578-38-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,5,7 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 74578-38:
(7*7)+(6*4)+(5*5)+(4*7)+(3*8)+(2*3)+(1*8)=164
164 % 10 = 4
So 74578-38-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H9FN2O3.C4H4N2O2/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12;7-3-1-2-5-4(8)6-3/h4,6H,1-3H2,(H,10,12,13);1-2H,(H2,5,6,7,8)
