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Usage

Uses

Used in the Chemical Industry:
(S)-(+)-2-HEPTYL ISOCYANATE, TECH. 90% is used as a building block for the synthesis of various organic compounds, such as polyurethane foams, coatings, adhesives, and elastomers. Its high reactivity makes it a valuable component in the production of these materials.
Used in the Plastics and Rubber Industry:
(S)-(+)-2-HEPTYL ISOCYANATE, TECH. 90% is used as a key component in the manufacturing of polyurethane foams, which are widely used in the plastics and rubber industry for various applications, including insulation, cushioning, and furniture production.
Used in the Coatings and Adhesives Industry:
(S)-(+)-2-HEPTYL ISOCYANATE, TECH. 90% is used as a raw material in the formulation of coatings and adhesives, providing improved properties such as durability, flexibility, and resistance to various environmental factors.
Used in the Elastomers Industry:
(S)-(+)-2-HEPTYL ISOCYANATE, TECH. 90% is used in the production of elastomers, which are essential materials in the manufacturing of various products such as tires, seals, and gaskets, due to their excellent elasticity and resilience.

Upstream product

• 123-82-0 2-heptylamine 
• 503-38-8 trichloromethyl chloroformate 
• 123-82-0 (R)-2-heptylamine 

Relevant academic research and scientific papers

Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates

A series of imidazole-containing (non-)chiral carbamates were tested at human histamine H3 receptor (H3R). All compounds displayed Ki values below 100 nM. A trend for a stereoselectivity at human H3R was observed for the chiral α-branched ligands. Selected compounds were also tested at human histamine H4 receptor and showed moderate to weak affinities (118-1460 nM).

Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: Synthesis, capillary electrophoresis, and in vitro and oral in vivo activity

Novel carbamates as derivatives of 3-(1H-imidazol-4-yl)propanol with an N-alkyl chain were prepared as histamine H3-receptor antagonists. Branching of the N-alkyl side chain with methyl groups led to chiral compounds which were synthesized stereospecifically by a Mitsunobu protocol adapted Gabriel synthesis. The optical purity of some of the chiral compounds was determined (ee > 95%) by capillary electrophoresis (CE). The investigated compounds showed pronounced to high antagonist activity (K(i) values of 4.1-316 nM) in a functional test for histamine H3 receptors on rat cerebral cortex synaptosomes. Similar H3-receptor antagonist activities were observed in a peripheral model on guinea pig ileum. No stereoselective discrimination for the H3 receptor for the chiral antagonists was found with the in vitro assays. All compounds were also screened for central H3-receptor antagonist activity in vivo in mice after po administration. Most compounds were potent agents of the H3-receptor-mediated enhancement of brain N(τ)- methylhistamine levels. The enantiomers of the N-2-heptylcarbamate showed a stereoselective differentiation in their pharmacological effect in vivo (ED50 of 0.39 mg/kg for the (S)-derivative vs 1.5 mg/kg for the (R)- derivative) most probably caused by differences in pharmacokinetic parameters. H1- and H2-receptor activities were determined for some of the novel carbamates, demonstrating that they have a highly selective action at the histamine H3 receptor.