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745783-81-7

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745783-81-7 Usage

General Description

(S)-(+)-1-INDANYL ISOCYANATE is a chemical compound that belongs to the class of isocyanates. It has a specific stereochemical configuration, indicated by the (S)-(+)- prefix in its name. Isocyanates are known for their reactivity and are commonly used in the production of polyurethane foams, coatings, and adhesives. (S)-(+)-1-INDANYL ISOCYANATE has a highly reactive isocyanate group, which makes it useful in the synthesis of various polymers and organic compounds. Due to its reactivity, it should be handled with care and proper safety precautions should be taken when working with this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 745783-81-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,5,7,8 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 745783-81:
(8*7)+(7*4)+(6*5)+(5*7)+(4*8)+(3*3)+(2*8)+(1*1)=207
207 % 10 = 7
So 745783-81-7 is a valid CAS Registry Number.

745783-81-7Downstream Products

745783-81-7Relevant articles and documents

Benzylic C-H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas

Krska, Shane W.,Lin, Shishi,Nkulu, Leah E.,Stahl, Shannon S.,Suh, Sung-Eun

, p. 10380 - 10387 (2021/08/12)

C(sp3)-H functionalization methods provide an ideal synthetic platform for medicinal chemistry; however, such methods are often constrained by practical limitations. The present study outlines a C(sp3)-H isocyanation protocol that enables the synthesis of diverse, pharmaceutically relevant benzylic ureas in high-throughput format. The operationally simple C-H isocyanation method shows high site selectivity and good functional group tolerance, and uses commercially available catalyst components and reagents [CuOAc, 2,2′-bis(oxazoline) ligand, (trimethylsilyl)isocyanate, andN-fluorobenzenesulfonimide]. The isocyanate products may be used without isolation or purification in a subsequent coupling step with primary and secondary amines to afford hundreds of diverse ureas. These results provide a template for implementation of C-H functionalization/cross-coupling in drug discovery.

Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach

Ni, Shuaishuai,Yuan, Yaxia,Huang, Jin,Mao, Xiaona,Lv, Maosheng,Zhu, Jin,Shen, Xu,Pei, Jianfeng,Lai, Luhua,Jiang, Hualiang,Li, Jian

supporting information; experimental part, p. 5295 - 5298 (2010/02/28)

This work describes an integrated approach of de novo drug design, chemical synthesis, and bioassay for quick identification of a series of novel small molecule cyclophilin A (CypA) inhibitors (1-3). The activities of the two most potent CypA inhibitors (3h and 3i) are 2.59 and 1.52 nM, respectively, which are about 16 and 27 times more potent than that of cyclosporin A. This study clearly demonstrates the power of our de novo drug design strategy and the related program LigBuilder 2.0 in drug discovery.

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