745795-94-2

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1402005-01-9 2-((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)ethan-1-ol 
• 86864-60-0 2-(tert-butyldimethylsilyloxy)ethyl bromide 

Downstream Products

• 745795-96-4 N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine 
• 745796-01-4 N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Orn}-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine 
• 745796-06-9 N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Dab}-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine 
• 745795-97-5 N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Lys}-O-(4,4'-dimethoxytrityl)diethanolamine 
• 745796-02-5 N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Orn}-O-(4,4'-dimethoxytrityl)diethanolamine 
• 745796-07-0 N-{N^α,N^ε-bis(pyrene-1-carbonyl)-L-Dab}-O-(4,4'-dimethoxytrityl)diethanolamine 
• 745795-95-3 N-L-Lys-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine 
• 745796-00-3 N-L-Orn-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine 
• 745796-05-8 N-L-Dab-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine 
• 745795-99-7 N-(N^α,N^ε-bis-Fmoc-L-Orn)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine 
• 745795-93-1 N-(N^α,N^ε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine 

Relevant academic research and scientific papers

THERAPEUTIC METHODS

The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.

METHODS FOR TREATING HEPATITIS B INFECTIONS

Certain embodiments of the invention provide a method for identifying a patient that has a higher likelihood of responding to an HBV antigen inhibitor, such a method comprising detecting a hepatitis B virus (HBV) infected patient's genotype at one or more of the IL28B/A associated SNPs described herein, wherein the relevant genotype(s) described herein are indicative of a patient that has a higher likelihood of responding to an HBV antigen inhibitor as compared to an HBV infected patient having different genotypes at these locations.

TARGETED COMPOSITIONS

The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS

The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Pyrene-labeled oligodeoxynucleotide probe for detecting base insertion by excimer fluorescence emission

Novel ODN probes for insertion polymorphism detection have been devised. The ODN probes labeled with two pyrene chromophores emit strong excimer fluorescence when hybridized with DNA containing one inserted base. This method is useful for the determinatio