7458-08-4 Usage
Description
N-nitrosodihydrodibenzazepine, also known as N-Nitrosoiminodibenzyl, is an N-nitroso derivative of 10,11-Dihydro-5H-dibenzo[b,f]azepine (D448870), a metabolite of the tricyclic antidepressant Imipramine (I465980). It is characterized by its unique chemical structure and potential therapeutic properties.
Uses
Used in Pharmaceutical Industry:
N-nitrosodihydrodibenzazepine is used as an antidepressant for treating various forms of depression. It is derived from Imipramine, a well-known tricyclic antidepressant, and may exhibit similar therapeutic effects in modulating neurotransmitter levels and alleviating depressive symptoms.
Additionally, N-nitrosodihydrodibenzazepine is used as an antiepileptic agent for managing epilepsy and seizure disorders. Its potential to modulate neuronal activity and reduce seizure frequency makes it a valuable compound in the development of new antiepileptic medications.
Used in Analytical Chemistry:
10,11-Dihydro-5H-dibenzo[b,f]azepine, the parent compound of N-nitrosodihydrodibenzazepine, is used as a chromogenic probe for the quantification of hydrogen peroxide and glucose. Its ability to change color in the presence of these analytes allows for accurate and sensitive detection, making it a valuable tool in analytical chemistry and research applications.
Check Digit Verification of cas no
The CAS Registry Mumber 7458-08-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,5 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 7458-08:
(6*7)+(5*4)+(4*5)+(3*8)+(2*0)+(1*8)=114
114 % 10 = 4
So 7458-08-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H12N2O/c17-15-16-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)16/h1-8H,9-10H2
7458-08-4Relevant articles and documents
Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy
Shang, Yaping,Jonnada, Krishna,Yedage, Subhash Laxman,Tu, Hua,Zhang, Xiaofeng,Lou, Xin,Huang, Shijun,Su, Weiping
supporting information, p. 9547 - 9550 (2019/08/15)
Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.
PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis
Roche, Didier,Lardy, Claude,Tournier, Lucie,Prunier, Marc,Valeur, Eric
experimental part, p. 2277 - 2280 (2010/05/19)
PS-SNAP was designed and evaluated as a practical nitrosating polymer-supported reagent for the nitrosation of sec-amines. Nitrosated dialkyl amines, alkyl anilines, and bis-anilines were obtained in good yields and high purities after shaking the corresponding amines in the presence of an excess of the newly described reagent followed by simple filtration and removal of solvents.
