74581-17-2Relevant academic research and scientific papers
INTRA VS INTERMOLECULAR AMIDOALKILATION OF AROMATICS
Ishai, D. Ben,Sataty, I.,Peled, N.,Goldshare, R.
, p. 439 - 450 (2007/10/02)
Three tipes of intramolecular amidoalkylation reactions of aromatics, two endotrigonal and one exotrigonal (I, II, III), leading to indolone, N-acylisoquinolines, isoquinolone and benzazepinone derivatives were studied.In the presence of external aromatic nucleophiles competing intermolecular amidoalkylations were observed (1->2, 13->14).The mechanism and the synthetic limitations of the three types of cyclization is discussed.
