745822-40-6

Basic information

• Product Name: 8-[(3-O-acetyl-2,4,6-tri-O-benzyl-α-D-mannopyranosyl)methyl]-O⁶-N²-(2-methylpropanoyl)guanine
• Synonyms: 8-[(3-O-acetyl-2,4,6-tri-O-benzyl-α-D-mannopyranosyl)methyl]-O⁶-N²-(2-methylpropanoyl)guanine
• CAS NO: 745822-40-6
• Molecular Weight: 799.924
• Mol File: 745822-40-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-[(3-O-acetyl-2,4,6-tri-O-benzyl-α-D-mannopyranosyl)methyl]-O⁶-N²-(2-methylpropanoyl)guanine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-[(3-O-acetyl-2,4,6-tri-O-benzyl-α-D-mannopyranosyl)methyl]-O⁶-N²-(2-methylpropanoyl)guanine(745822-40-6)
• EPA Substance Registry System: 8-[(3-O-acetyl-2,4,6-tri-O-benzyl-α-D-mannopyranosyl)methyl]-O⁶-N²-(2-methylpropanoyl)guanine(745822-40-6)

Safety Data

• Hazardous Substances Data: 745822-40-6(Hazardous Substances Data)

Upstream product

• 745822-38-2 2-(3-O-acetyl-2,4,6-tri-O-benzyl-α-D-mannopyranosyl)-N-[2-amino-6-(benzyloxy)-5-nitrosopyrimidin-4-yl]acetamide 
• 100-51-6 benzyl alcohol 
• 100061-59-4 NU₆₀₃₈ 
• 101724-61-2 2,4-diamino-6-(benzyloxy)-5-nitrosopyrimidine 
• 97-72-3 2-Methylpropionic anhydride 
• 745822-39-3 8-[(3-O-acetyl-2,4,6-tri-O-benzyl-α-D-mannopyranosyl)methyl]-O⁶-benzylguanine 

Downstream Products

• 745822-42-8 O⁶-benzyl-N²-(2-methylpropanoyl)-8-[(2,4,6-tri-O-benzyl-α-D-mannopyranosyl)methyl]guanosine 
• 745822-41-7 8-[(3-O-acetyl-2,4,6-tri-O-benzyl-α-D-mannopyranosyl)methyl]-2',3',5,'-tri-O⁶-benzoyl-N²-(2-methylpropanoyl)guanosine 

Relevant articles and documents

Preparation of an advanced intermediate for the synthesis of stable analogues of guanofosfocin

The synthesis of C-mannosyl-guanosine 23, an advanced intermediate for the preparation of stable analogues of guanofosfocin, is described. This convergent approach features an improved Traube-type synthesis of a 8-substituted guanine, followed by ribosylation. NMR Studies show that the C-mannopyranosyl moiety of 23 adopts a distorted 1C4 conformation while the nucleoside is predominantly syn-oriented.