74598-06-4

Usage

Uses

Used in Organic Synthesis:
Ethyl 5-chloro-4-formylthiophene-2-carboxylate is used as a building block for the synthesis of more complex organic molecules. Its unique structure allows for further chemical reactions and modifications, making it a valuable component in the creation of advanced organic compounds.
Used in Pharmaceutical Industry:
Ethyl 5-chloro-4-formylthiophene-2-carboxylate is used as a precursor for the preparation of pharmaceutical drugs. Its chemical properties and functional groups make it a promising candidate for the development of new medications with potential therapeutic benefits.
Used in Material Science:
Ethyl 5-chloro-4-formylthiophene-2-carboxylate is used in the development of electronic materials, such as organic semiconductors. The presence of the thiophene ring in its structure suggests potential applications in this field, contributing to the advancement of electronic devices and technologies.
Safety Precautions:
As with any chemical compound, proper handling and safety precautions should be taken when working with ethyl 5-chloro-4-formylthiophene-2-carboxylate to ensure the safety of individuals and the environment.

Upstream product

• 74598-04-2 5-chloro-4-methyl-2-thiophenecarboxylic acid ethyl ester 
• 91505-29-2 5-Chloro-4-methyl-thiophene-2-carbonyl chloride 
• 74598-03-1 5-chloro-4-methylthiophen-2-carboxylic acid 
• 14345-97-2 2-chloro-3-methylthiophene 
• 74598-05-3 ethyl 5-chloro-4-(dibromomethyl)thiophen-2-carboxylate 

Downstream Products

• 74598-11-1 ethyl thieno<3,2-d>isothiazole-5-carboxylate 

Relevant academic research and scientific papers

Condensed Isothiazoles. Part 5. Thienoisothiazoles and Thienoisothiazoles

2,3-Disubstituted thiophens containing a sulphur function (SH, SMe, or SCN) and a carbonyl group (CHO or Ac) have been prepared and converted into thienoisothiasoles.Methods used to prepare 1,2-benzisothiazoles are often inapplicable in the thiophen series.For example, an (E)-methyl (2-methylthio-3-thienyl) O-p-nitrobenzoylketoxime (6) in hot diethylene glycol or acetic acid gave the corresponding 3-acetamido-2-methylthiothiophen (15); in concentrated sulphuric acid at - 5 deg C, it gave the Beckmann rearranged product (15) and a thienothiazole (19).Similarly, (E)-methyl (3-methylthio-2-thienyl) O-p-nitrobenzoyl ketoxime (42) gave 2-methylthienothiazole with concentrated sulphuric acid, but with acetic acid it gave the thienoisothiazole (43) and 2-acetamido-3-methylthiothiophen.Heating the (E)-2-mercaptothiophen-3-carbaldoxime (27) in an inert solvent gave the corresponding thienoisothiazole (14); the (E)-3-mercaptothiophen-2-carbaldoxime (47) cyclised in hot AcOH-Ac2O, to give the thienoisothiazole (44).Thienoisothiazoles were also prepared by treating a methyl (2-mercapto-3-thienyl) ketone (21) with chloramine and by heating a 2-iminothieno-3,1,4-oxathiazepine (29) in an inert solvent.The products obtained by selective S-alkylation of 3,5-bis(sodiomercapto)isothiazole-4-carbonitrile with ethyl bromoacetate and iodomethane were cyclised, to give 4-aminothienoisothiazole derivatives (34) and (36).