74608-34-7Relevant academic research and scientific papers
BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6
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Paragraph 00363; 00364, (2018/12/13)
The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.
Desamination of β- and γ-Amino Alcohols
Guenther, Bernd-Rainer,Kirmse, Wolfgang
, p. 518 - 532 (2007/10/02)
Nitrous acid deaminations of the β-amino alcohols 2 and 12 afford 1,2 diols as well as ketones by pinacolic rearrangement.Both types of products arise with predominant inversion of configuration.Stereochemical studies and isotopic labeling reveal that formation of the diols involves an oxygen shift, presumably via oxirane intermediates.Deamination of the γ-amino alcohol 37 induces, in part, sequential rearrangements to give products also obtained from 12, but in different proportions and enantiomeric purities.Conformational control provides a reasonable explanation of our results.
