7461-11-2

Usage

Uses

Used in Organic Synthesis:
2-chloroquinolin-8-aMine is used as a building block in organic synthesis for the preparation of various pharmaceutical compounds and other organic molecules. Its unique structure allows for the creation of a wide range of derivatives with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-chloroquinolin-8-aMine is used as a key intermediate in the synthesis of drugs with potential therapeutic applications. Its ability to be modified and incorporated into complex molecular structures makes it a valuable component in the development of new medications.
Used in Medicinal Chemistry Research:
2-chloroquinolin-8-aMine is utilized in medicinal chemistry research as a subject of interest due to its potential biological activities. Researchers explore its interactions with biological targets to understand its effects and potential uses in treating various diseases and conditions.
Used in Dye and Pigment Industry:
Although not explicitly mentioned in the provided materials, given its quinoline base, 2-chloroquinolin-8-aMine could also be used in the dye and pigment industry for the development of new colorants and pigments, leveraging its chemical structure to create novel compounds with specific color properties.

InChI:InChI=1/C9H7ClN2/c10-8-5-4-6-2-1-3-7(11)9(6)12-8/h1-5H,11H2

Upstream product

• 4225-86-9 2-chloro-8-nitroquinoline 
• 612-62-4 2-Chloroquinoline 

Relevant academic research and scientific papers

Effects of the Distance between Radical Sites on the Reactivities of Aromatic Biradicals

Coupling of the radical sites in isomeric benzynes is known to hinder their radical reactivity. In order to determine how far apart the radical sites must be for them not to interact, the gas-phase reactivity of several isomeric protonated (iso)quinoline-and acridine-based biradicals was examined. All the (iso)quinolinium-based biradicals were found to react slower than the related monoradicals with similar vertical electron affinities (i.e., similar polar effects). In sharp contrast, the acridinium-based biradicals, most with the radical sites farther apart than in the (iso)quinolinium-based systems, showed greater reactivities than the relevant monoradicals with similar vertical electron affinities. The greater distances between the two radical sites in these biradicals lead to very little or no spin-spin coupling, and no suppression of radical reactivity was observed. Therefore, the radical sites can still interact if they are located on adjacent benzene rings and only after being separated further than that does no coupling occur. The most reactive radical site of each biradical was experimentally determined to be the one predicted to be more reactive based on the monoradical reactivity data. Therefore, the calculated vertical electron affinities of relevant monoradicals can be used to predict which radical site is most reactive in the biradicals.

QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.