74618-04-5Relevant academic research and scientific papers
1,3-Dipolar Cycloaddition of Alkyne-Tethered N-Tosylhydrazones: Synthesis of Fused Polycyclic Pyrazoles
Zheng, Yang,Zhang, Xiaolu,Yao, Ruwei,Wen, Yuecheng,Huang, Jingjing,Xu, Xinfang
, p. 11072 - 11080 (2016/11/28)
A general and transition-metal-free access to the fused polycyclic pyrazoles via an intramolecular 1,3-dipolar cycloaddition reaction of alkyne-tethered tosylhydrazones has been reported. The pure solid products could be obtained without column chromatography in high to excellent yields, and the obtained products are useful bioactive molecules or could be used as the key intermediate for synthesis of these compounds in one or two steps. Additionally, a [3+2]-cycloaddition followed by a direct H-shift aromatization reaction mechanism was proposed, which is different from the previously reported aryl or alkyl sequential [1,5]-sigmatropic rearrangement pathway.
Antifertility Agents: Part XLIII - Synthesis of 3-Aryl-4,5-dihydro-2-substituted-5-tosyl-2H-pyrazoloquinolines and 2,4-Dihydro-3-phenylbenzopyranopyrazoles and Their Derivatives
Sangwan, Naresh K.,Kelkar, Prabhakar M.,Rastogi, Shri Nivas,Anand, N.
, p. 639 - 644 (2007/10/02)
2,3-Dihydro-1-tosyl-4(1H)-quinolones (5-7) on formylation give the corresponding 3-hydroxymethylene derivatives (11-13) of which 12 and 13 react with piperazine to afford N,N-bis-substituted piperazines (15 and 16).Refluxing of 11-13 with substituted hydr
Intramolecular Cycloaddition Reactions of N-Sulfonyl Nitrile Imides Bearing Alkenyl Groups
Shimizu, Tomio,Hayashi, Yoshiyuki,Nagano, Yoshio,Teramura, Kazuhiro
, p. 429 - 434 (2007/10/02)
The reaction of the p-tolyl(or phenyl)sulfonylhydrazones of some 2-(alkenyloxy)benzaldehydes with lead tetraacetate leads, via the nitrile imide intermediates, Ar-C(+)=N-N(-)-SO2-C6H4-X-p, to intramolecular 1,3-dipolar cycloadducts and 1-acetyl-2-aroyl-1-
