74619-50-4

Basic information

• Product Name: bis-3,5-(2'-hydroxyphenyl)-1H-1,2,4-triazole
• Synonyms: bis-3,5-(2'-hydroxyphenyl)-1H-1,2,4-triazole
• CAS NO: 74619-50-4
• Molecular Weight: 253.26
• Mol File: 74619-50-4.mol

Chemical Properties

• CAS DataBase Reference: bis-3,5-(2'-hydroxyphenyl)-1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: bis-3,5-(2'-hydroxyphenyl)-1H-1,2,4-triazole(74619-50-4)
• EPA Substance Registry System: bis-3,5-(2'-hydroxyphenyl)-1H-1,2,4-triazole(74619-50-4)

Safety Data

• Hazardous Substances Data: 74619-50-4(Hazardous Substances Data)

Upstream product

• 65-45-2 salicylamide 
• 69-72-7 salicylic acid 
• 53638-81-6 2,2’-(4-amino-4H-1,2,4-triazole-3,5-diyl)diphenol 
• 63963-47-3 6,6'-(1,2,4-Dithiazolidin-3,5-yliden)-bis-2,4-cyclohexadien-1-on 
• 1218-69-5 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one 
• 74619-49-1 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-oxadiazole 
• 613-94-5 benzoic acid hydrazide 
• 1441-87-8 salicyloyl chloride 
• 1972-71-0 2-hydroxy-N-(2-hydroxybenzoyl)benzamide 
• 90681-68-8 <2-(2-Hydroxyphenyl)-1,3-benzoxazin-4-yliden>-4-nitrophenylacetonitril 
• 86245-83-2 2-(o-hydroxyphenyl)-4-oxo-1,3-benzoxazinium perchlorate 

Downstream Products

• 110981-88-9 Co⁽²⁺⁾*C₂HN₃(C₆H₄O)2^(2-)=Co(C₂HN₃(C₆H₄O)2) 
• 110981-87-8 Ni⁽²⁺⁾*C₂HN₃(C₆H₄O)2^(2-)=Ni(C₂HN₃(C₆H₄O)2) 
• 110981-86-7 Cu⁽²⁺⁾*C₂HN₃(C₆H₄O)2^(2-)=Cu(C₂HN₃(C₆H₄O)2) 

Relevant articles and documents

Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties

Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of iron overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge transfer, and through-bond and through-space conjugation characteristics in aqueous media. Functionalization of the phenol units on the deferasirox scaffold afforded the fluorescent responsive pro-chelator ExPhos, which enabled the detection of the disease-based biomarker alkaline phosphatase (ALP). The diagnostic potential of these deferasirox derivatives was supported by bacterial biofilm studies.

Synthesis and biological evaluation of 1,2,4-oxadiazole core derivatives as potential neuroprotectants against acute ischemic stroke

Here, we report the synthesis and neuroprotective capacity of 27 compounds with a bisphenol hydroxyl-substituted 1,2,4-triazole core or 1,2,4-oxadiazole core for stroke therapy. In vitro studies of the neuroprotective effects of compounds 1–27 on sodium nitroprusside (SNP)-induced apoptosis in PC12 cells indicate that compound 24 is the most effective compound conferring potent protection against oxidative injury. Compound 24 inhibits reactive oxygen species (ROS） accumulation and restores the mitochondrial membrane potential (MMP). Moreover, further analysis of the mechanism showed that compound 24 activates the antioxidant defence system by promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and increasing the expression of haem oxygenase 1 (HO-1). An in vivo study was performed in a rat model of transient focal cerebral ischaemia generated by the intraluminal occlusion of the middle cerebral artery (MCAO). Compound 24 significantly reduced brain infarction and improved neurological function. Overall, compound 24 potentially represents a promising compound for the treatment of stroke.

Synthesis, Biological Evaluation and Molecular Docking of Deferasirox and Substituted 1,2,4-Triazole Derivatives as Novel Potent Urease Inhibitors: Proposing Repositioning Candidate

A series of new deferasirox derivatives were synthesized through the reaction of monosubstituted hydrazides with 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one. For the first time, deferasirox and some of its derivatives were evaluated for their in vitro inhibitory activity against Jack bean urease. The potencies of the members of this class of compounds are higher than that of acetohydroxamic acid. Two compounds, bearing tetrazole and hydrazine derivatives (bioisoester of carboxylate group), represented the most potent urease inhibitory activity with IC50 values of 1.268 and 3.254 μm, respectively. In silico docking studies were performed to delineate possible binding modes of the compounds with the enzyme, urease. Docking analysis suggests that the synthesized compounds were anchored well in the catalytic site and extending to the entrance of binding pocket and thus restrict the mobility of the flap by interacting with its crucial amino acid residues, CME592 and His593. The overall results of urease inhibition have shown that these target compounds can be further optimized and developed as a lead skeleton for the discovery of novel urease inhibitors.

1,2,4-triazole compound, salt thereof and applications of compound and salt

The invention discloses a 1,2,4-triazole compound, salt thereof and applications of the compound and salt. The compound has a structural formula shown in the description, wherein R represents hydrogen, phenyl or substituted phenyl, and a substituted group of substituted phenyl is selected from carboxyl, an ester group, C1-4 alkyl, C1-4 alkoxy groups, C1-4 halogenated alkyl, C1-4 halogenated alkoxygroups, C2-4 alkynyl, halogen, cyano groups, acyl, nitryl or hydroxyl. The compound has high insecticidal activity for aphids, part of compound has the insecticidal activity for aphids equivalent tothat of a commercial insecticide dinotefuran, and the compound can be used for controlling lepidoptera pests, coleoptera pests, heteropteran pests, diptera pests, orthoptera pests and homoptera pests.

Proton transfer triggered proton transfer: A self-assisted twin excited state intramolecular proton transfer

The double excited state intramolecular proton transfer (ESIPT) of 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole (bis-HPTA), a molecule possessing two intramolecular hydrogen bonded donor-acceptor pairs, has been investigated. The molecule undergoes not only

An improved procedure for the deamination of symmetrical 3,5-disubstituted 4-amino-1,2,4-triazoles

A number of symmetrical 3,5-disubstituted-4H-1,2,4-triazoles have been synthesized in good yields by deamination of the corresponding 4-amino-1,2,4-triazoles via reductive diazotation of these amino compounds in the presence of hypophosphorous acid. Analy

SYNTHESIS OF BIS(o-HYDROXYPHENYL)-1,3,5-TRIAZINES, 1,2,4-TRIAZOLES, AND OXADIAZOLE BY RECYCLIZATION OF THE o-HYDROXYPHENYL-4-OXO-1,3-BENZOXAZINIUM CATION

The acidic cyclization of disalicylamide gave 2-(o-hydroxyphenyl)- and 2-(o-acetoxyphenyl)-4-oxo-1,3-benzoxazinium perchlorates, by reaction of which with hydroxylamine, hydrazines, benzamidine, guanidines, and S-methylisothiourea bis(o-hydroxyphenyl)-1,2