74634-66-5Relevant academic research and scientific papers
SUBSTITUTED ACETANILIDES AND BENZAMIDES FOR THE TREATMENT OF ASTHMA AND PULMONARY INFLAMMATION
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Page/Page column 42, (2008/06/13)
Substituted acetanilide or benzamide compositions or formulations for delivery by aerosolization are described. The formulation contains an efficacious amount of acetanilide or benzamide compound able to inhibit inflammation in asthmatic lungs. Compounds of the invention are formulated in 5 ml solution of a quarter normal saline having pH between 5.0 and 7.0. The method for treatment of respiratory tract inflammation by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 μ, produced by nebulization or dry powder inhaler.
Cyclizing compounds. 3. Local anesthetic action of N (ω haloalkyl) N methylaminoaceto 2,6 xylidides
Ross,Sandberg,Akerman,Domeij,Stening,Svensson
, p. 787 - 790 (2007/10/06)
A series of N (ω chloroalkyl) N methylaminoaceto 2,6 xylidides which are able to cyclize to quaternary ammonium derivates was synthesized and examined for local anesthetic action. As reference compounds the corresponding series of N alkylamine derivates were synthesized and tested. In both series of compounds the duration of anesthesia was prolonged by increasing the size of the side chain. In the N alkylamine series an optimal effect was obtained for the N hexylamine derivate. The duration of anesthesia produced by the cyclizing compounds in the sciatic nerve test in vivo was somewhat shorter than that for the noncyclizing compounds. The observation that the N 4 chlorobutyl derivate produced a longer block than the 5 chloropentylamine in this test indicates that the quaternary compounds formed may contribute to the duration of anesthesia.
