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Docarpamine is a cardiostimulant with diuretic activity, launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, exerting renal vasodilatory and natriuretic effects by activating renal dopamine (DA1) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock, and acute renal failure.

74639-40-0

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Basic information
1. Product Name: Docarpamine
2. Synonyms: Docarpamine;Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester;Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-;TA 870;Tanadopa;(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide;3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine;TA-8704
3. CAS NO:74639-40-0
4. Molecular Formula: C21H30N2O8S
5. Molecular Weight: 470.54
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 74639-40-0.mol
Chemical Properties
1. Melting Point: 85-90°; mp 105-108° (Nishiyama, 1992)
2. Boiling Point: 731°C at 760 mmHg
3. Flash Point: 395.9°C
4. Appearance: /
5. Density: 1.222g/cm³
6. Vapor Pressure: 3.14E-21mmHg at 25°C
7. Refractive Index: 1.529
8. Storage Temp.: N/A
9. Solubility: N/A
10. PKA: 14.51±0.46(Predicted)
11. CAS DataBase Reference: Docarpamine(CAS DataBase Reference)
12. NIST Chemistry Reference: Docarpamine(74639-40-0)
13. EPA Substance Registry System: Docarpamine(74639-40-0)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 74639-40-0(Hazardous Substances Data)

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74639-40-0 Usage

Uses

Used in Cardiac Surgery:
Docarpamine is used as an alternative to intravenous dopamine after cardiac surgery for its cardiostimulant and diuretic properties, which help in the treatment of circulatory insufficiency and acute heart failure.

Check Digit Verification of cas no

The CAS Registry Mumber 74639-40-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,6,3 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 74639-40:
(7*7)+(6*4)+(5*6)+(4*3)+(3*9)+(2*4)+(1*0)=150
150 % 10 = 0
So 74639-40-0 is a valid CAS Registry Number.

InChI:InChI=1/C21H30N2O8S/c1-5-28-20(26)30-17-8-7-15(13-18(17)31-21(27)29-6-2)9-11-22-19(25)16(10-12-32-4)23-14(3)24/h7-8,13,16H,5-6,9-12H2,1-4H3,(H,22,25)(H,23,24)/t16-/m0/s1

74639-40-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylene diethyl bi scarbonate

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74639-40-0 SDS

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