7464-74-6Relevant academic research and scientific papers
Alkyl migrations in the thermal transformation of 2,6-dialkoxy-7,9-dimethylpurinium iodides leading to 1,3,7-trialkylxanthines
Kowalska,Maslankiewicz
, p. 454 - 459 (2007/10/03)
2,6-Dialkoxy-7,9-dimethylpurinium iodides 1 undergo thermal transformation to 1,3,7-trialkylxanthines 2 as a result of C6O → Nx, C2O → NX, N9 → Nx, and N7 → Nx (when x = 1, 3 or 7) alkyl group migration. Intra-or intermolecular character of rearrangement was studied using deuterium-labelled derivatives of 1, and by cross-over experiment with salts 1a* and 1c. The 1H NMR spectra of 1,3,7-trialkylxanthines 2 (R = Me, Et) are presented.
