74647-29-3

Upstream product

• 74647-28-2 3-amino-3-(o-aminoanilino)-2-cyano-2-propenaloxime 
• 109856-07-7 N-(3-cyano-1H-1,5-benzodiazepin-4-yl)-N'-ethylurea 
• 109948-71-2 4-ethoxycarbonylamino-1H-1,5-benzodiazepine-3-carbonitrile 
• 42510-46-3 4-amino-1H-1,5-benzodiazepine-3-carbonitrile hydrochloride 

Downstream Products

• 123772-63-4 2-benzimidazolidinylidene-3-hydroxyiminopropionitrile 
• 123772-64-5 5-(o-aminoanilino)4-cyanoisoxazole monohydrochloride 

Relevant academic research and scientific papers

Ring Transformation of 4-Amino and 4-N-(Substituted)amino-1H-1,5-benzodiazepine-3-carbonitriles with Hydroxylamine. A New Synthesis of Benzimidazolidine and Izoxazole Derivatives

The reaction of 4-amino-1H-1,5-benzodiazepine-3-carbonitrile 1 with hydroxylamine provided the ring-opened hydroxyamine adduct 2 which was converted to 2-benzimidazolidinylidene-3-hydroxyiminopropionitrile 4 in hydrochloric acid.The reaction of 4-ethoxyca

Ring transformation of 4-amino-1H-1,5-benzodiazepine-3-carbonitrile. The use of hydroxylamines as nucleophile

The reaction of 4-amino-1H-1,5-benzodiazepine-3-carbonitrile hydrochloride (I) with hydroxylamine gave a ring-opened compound, 3-amino-3-(o-aminoanilino)-2-cyano-2-propenaloxime (5). Compound 5 was converted to 5-(o-aminoanilino)-4-cyanoisoxazole (6) on t