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Upstream product

• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 
• 504-02-9 1,3-cylohexanedione 
• 91-56-5 indole-2,3-dione 
• 109-77-3 malononitrile 
• 6532-16-7 1-(4-morpholinylmethyl)-1H-indole-2,3-dione 
• 151-18-8 2-cyanoethylamine 

Relevant academic research and scientific papers

Novel cellulose supported 1,2-bis(4-aminophenylthio)ethane Ni(ii) complex (NiII(BAPTE)(NO3)2-Cell) as an efficient nanocatalyst for the synthesis of spirooxindole derivatives

Cellulose was used as a support for immobilizing a Ni(ii) complex of 1,2-bis(4-aminophenylthio)ethane to prepare NiII(BAPTE)(NO3)2-Cell as a new organo-inorganic hybrid nanocatalyst. The properties of the prepared catalyst were studied using various analy

Environmentally friendly synthesis of Ag/SiO2 nanoparticles using Thymus kotschyanus extract and its application as a green catalyst for synthesis of spirooxindoles

Today, plant extracts based on synthetic procedures have drawn consideration over conventional methods like physical and chemical procedures to synthesize nanomaterials. Green synthesis of nanomaterials has become an area of interest because of numerous advantages such as non-hazardous, economical, and feasible methods with a variety of applications in biomedicine, nanotechnology and nano-optoelectronics and as catalysts for various organic transformations. In this research, silver nanoparticles were deposited on the surface of nano-silica spheres by an in-situ reduction of Ag+ ions using an aqueous extract of Thymus kotschyanus aerial parts as a natural reducing and a capping agent. The result recorded from ultraviolet–visible (UV–Vis) spectrometer, Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM–EDS) and X-ray powder diffraction supports the biosynthesis and characterization of Ag/SiO2 nanoparticles. The results indicated that the average size of Ag/SiO2 nanoparticles is 25–60?nm. The Ag/SiO2 nanoparticles act as an environmentally friendly heterogeneous catalyst in the synthesis of spirooxindoles via the three-component condensation reaction of isatins, activated methylene reagents, and 1,3-dicarbonyl compounds in aqueous media, and the desired products were obtained with yields ranging from 90 to 98%. The catalyst can be recovered easily and used repetitively without significant loss of catalytic activity. Graphical abstract: [Figure not available: see fulltext.].

Green synthesis and antibacterial, antifungal activities of 4H-pyran, tetrahydro-4H-chromenes and spiro2-oxindole derivatives by highly efficient Fe3O4@SiO2@NH2@Pd(OCOCH3)2 nanocatalyst

An efficiently, magnetically retrievable Fe3O4@SiO2@NH2@Pd(OCOCH3)2 nanoparticles was successfully synthesized and affirmed by several physicochemical characterization tools, such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-disoersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), and power X-ray diffraction. Thereafter, the catalytic performance of this environmentally benign nanocatalyst was investigated in the one-pot multicomponent synthesis of biologically important 2-amino-3-cyano-4H-pyran, tetrahydro-4H-chromenes and spiro2-oxindole derivatives. The reaction was simply achieved via one-pot three-component reaction of arylaldehydes, malononitrile and dimedone/isatins/methylaceto acetate ethanol at room temperature, with excellent yields and high purity. A new catalytic system, recyclability of reaction medium, little reaction times and excellent yields with easy workup render this protocol more attractive and economically viable.

Click approach to the novel 1,2,3-triazolium phosphotungstate organic–inorganic hybrids for the highly promoted synthesis of spirooxindoles

The synthesis and catalytic activity of three 1,2,3-triazole-based ionic organic–inorganic hybrids as novel water-soluble catalysts for the efficient preparation of spirooxindole derivatives are described. At first, three different 1,2,3-triazoles were prepared by click reaction. Then, these synthesized compounds were reacted with 1,4-butane sultone to generate novel solid 1,2,3-triazolium-N-butyl sulfonate zwitterions. In the next step, the newly synthesized organic zwitterions were treated with an aqueous solution of phosphotungstic acid to give three novel 1,2,3-triazolium-N-butyl sulfonic acid phosphotungstates as targeted organic–inorganic hybrid catalysts. The prepared catalysts were fully characterized using FTIR, 1H and 13C NMR, XRD, elemental analysis (CHNS), ESI–MS, DSC, and TG techniques. The introduced novel SO3H-functionalized ionic hybrid catalysts have a cationic organic triazolium with phosphotungstate anion and are water-soluble with appropriate thermal stability. Their catalytic activity was explored for the synthesis of spirooxindoles via the three‐component reaction of 1,3‐dicarbonyl compounds, barbituric acid, and isatin derivatives. The synthesis of desired spirooxindole products was performed in acceptable times with excellent yields in the presence of low loading amount of the prepared 1,2,3-triazolium-N-butyl sulfonic acid phosphotungstate catalysts (10?mmol%) in water. Some highlighted superiorities of the introduced organic–inorganic hybrids in comparison with most of the previously reported catalysts are as follows: clean and straightforward preparation, novelty of the catalysts, green conditions, ease of recovery, and reusability up to three repeated runs with no significant decrease in the catalytic stability. Graphical abstract: [Figure not available: see fulltext.]

Efficient synthesis of spirooxindole derivatives by magnetic and recyclable CaFe2O4@MgAl-LDH

A promising chemotherapeutic agent is spirooxindole. Probable targets involve cancers of the lung, liver, breast, colon, stomach, and prostate. Widespread drug discovery applications and biological activity are significant synthetic targets of spirooxindo

Green synthesis of trimetallic oxide nanoparticles and their use as an efficient catalyst for the green synthesis of quinoline and spirooxindoles: Antibacterial, cytotoxicity and anti-colon cancer effects

The three-metallic oxide (Cu/Cr/Ni) nanoparticles were prepared using Echinops persicus plant extract via a simple, biocompatible, cost-effective, and non-toxic procedure, and their catalytic activity was evaluated over the synthesis of biologically activ

A green and sustainable approach for the synthesis of 1,5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal-organic framework as a reusable catalyst

Metal-organic framework MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1,5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT

An efficient one-pot multi-component synthesis of spirooxindoles using Fe3O4/g-C3N4 nanocomposite as a green and reusable catalyst in aqueous media

In this study, an efficacious method is described for the synthesis of spirooxindole derivatives using Fe3O4/g-C3N4 as a green catalyst. This is a one-pot three-component condensation in water as a clean and environmentally favorable media. The present procedure proposes various remarkable privileges such as mild reaction conditions, simple work-up procedure and environment friendly. Moreover, the catalyst used is easily recovered by the external magnetic field and reused without significant deterioration in catalytic activity after at least six times.

Guanine base stabilized on the magnetic nanoparticles as recyclable catalyst “on water” for the synthesis of spirooxindole derivatives

Guanine stabilized on the surface of silica-modified magnetic nanoparticles, by the propyl group as a linker, (Fe3O4@SiO2-n-(propyl)-guanine), was prepared, identified and used as a recyclable base in the synthesis of novel spirooxindole compounds and highly substituted dihydro-2-oxopyrroles in aqueous media. Fe3O4@SiO2-n-(propyl)-guanine was characterized via some spectroscopic and microscopic techniques such as Infrared spectroscopy (IR), X-ray diffraction spectroscopy (XRD), Energy dispersive X-ray spectroscopy (EDX), Vibrating sample magnetometry (VSM), Scanning electron microscopy (SEM), High resolution transmission electron microscopy (HR-TEM), Thermo-gravimetric analysis (TGA) and NMR-detected hydrogen/deuterium (H/D) exchange technique. The synthesized nanocomposite was employed as a new base catalyst for the synthesis of some novel spirooxindole compounds and highly substituted dihydro-2-oxopyrroles in aqueous media with good to excellent yields. This heterogeneous base catalyst could be recycled and reused up to ten times without appreciable loss of activity.

Efficient Synthesis of 4H-Pyran and Spiro-Oxindole Derivatives Based on Al2O3/V2O5 Nanocomposite as Catalyst

Abstract: A simple and eco-friendly catalytic alternative has been proposed for one-potthree-component synthesis of 4H-pyrane andspiro-oxindole derivatives, as two important classes of potentially bioactivecompounds, in the presence of a catalytic amount