7465-16-9Relevant academic research and scientific papers
Preparation method of 3-bromo-4-hydroxybenzaldehyde
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Paragraph 0036-0038, (2020/02/19)
The invention discloses a preparation method of 3-bromo-4-hydroxybenzaldehyde. The preparation method comprises the following steps: (1) carrying out a bromination reaction on p-hydroxybenzene methylal and bromine to obtain 3-bromo-4-hydroxybenzene methylal; and (2) carrying out a hydrolysis reaction on the 3-bromo-4-hydroxybenzene methylal obtained in the step (1), and carrying out post-treatmentafter the reaction is finished to obtain the 3-bromo-4-hydroxybenzaldehyde. According to the preparation method, aldehyde is replaced with acetal for the bromination reaction, so that generation of adibromo product is effectively avoided, the yield and purity of a monobromo product are improved, and industrialization is facilitated.
A facile and efficient protocol for esterification and acetalization in a PEG1000-D(A)IL/toluene thermoregulated catalyst-media combined systems
Wang, Yinglei,Zhi, Huizhen,Luo, Jun
, p. 46 - 52 (2013/09/23)
A novel efficient and recyclable temperature-dependent biphasic catalyst and reaction media combined system comprised of PEG-1000 linked dicationic acidic ionic liquid and toluene was developed and applied in esterification of aromatic acids and acetalization of aromatic aldehydes with good to excellent yields. This system is characteristic of temperature-dependent reversible biphasic property, simple and facile recyclability, high catalytic activity and extensive substrate and reaction adaptability.
Bronsted acidic ionic liquids as efficient and recyclable catalysts for protection of carbonyls to acetals and ketals under mild conditions
Du, Yuying,Tian, Fuli
, p. 2703 - 2708 (2007/10/03)
A series of acidic ionic liquids have been used as efficient catalysts for the protection of various carbonyl compounds at room temperature. The features of mild conditions, satisfactory isolated yield, simple workup, and the recyclability of the catalyst were present in this process. Copyright Taylor & Francis, Inc.
Sulfamic acid as a cost-effective and recyclable catalyst for protection of carbonyls to acetals and ketals under mild conditions
Gong, Weizhong,Wang, Bo,Gu, Yanglong,Yan, Liang,Yang, Liming,Suo, Jishuan
, p. 4243 - 4247 (2007/10/03)
An efficient H2NSO3H-catalyzed protection of various carbonyl compounds at room temperature was investigated. The features of mild conditions, cost-efficient catalyst, simple workup, and the recyclability of the catalyst were represented in this process.
An efficient and versatile procedure for the synthesis of acetals from aldehydes and ketones catalyzed by lithium tetrafluoroborate
Hamada, Nao,Kazahaya, Kiyoshi,Shimizu, Hisashi,Sato, Tsuneo
, p. 1074 - 1076 (2015/10/07)
Acetals are obtained in good to excellent yields by treatment of aldehydes and ketones with trialkyl orthoformate and the corresponding alcohol in the presence of a catalytic amount of lithium tetrafluoroborate. Due to the mild reaction conditions, this method is compatible with acid-sensitive substrates.
Tetrabutylammonium tribromide (TBATB) as an efficient generator of HBr for an efficient chemoselective reagent for acetalization of carbonyl compounds
Gopinath, Rangam,Haque, Sk. Jiaul,Patel, Bhisma K.
, p. 5842 - 5845 (2007/10/03)
Acyclic and cyclic acetals of various carbonyl compounds were obtained in excellent yields under a mild reaction condition in the presence of trialkyl orthoformate and a catalytic amount of tetrabutylammonium tribromide (TBATB) in absolute alcohol. Chemoselective acetalization of an aldehyde in the presence of ketone, unsymmetrical acetal formation, shorter reaction times, mild reaction conditions, the stability of acid-sensitive protecting groups, high efficiencies, facile isolation of the desired products, and the catalytic nature of the reagent make the present methodology a practical alternative.
