74652-47-4Relevant academic research and scientific papers
1,3-Dipolar cycloaddition reaction: Synthesis of novel 5,6- dehydronorcantharidin derivatives of substituted aromatic amines with potential antitumor activities
Deng, Li-Ping,Liu, Fang-Ming,Wang, Hou-Yong
, p. 13 - 18 (2005)
Twelve novel compounds were synthesized by the [3+2] 1,3-dipolar cycloaddition reaction of 5,6-dehydronorcantharidin derivatives of substituted aromatic amines with nitrile oxides. The structure and the configuration of all compounds were confirmed by 1H NMR, IR, MS, 1H- 1HCOSY, and NOESY spectral data. Their anti-tumor activities are under way.
Synthesis of Isoxazole-Linked Norcantharidin Analogues of Substituted Chromones
Wang, Wei,Deng, Liping,Hu, Chunqi,Zhang, Yaohong,Li, Yan,Zuo, Shufeng
, p. 1806 - 1811 (2017/05/29)
Eighteen novel norcantharidin derivatives, which were substituted by chromone ring, were synthesized in a single step by the [3 + 2] 1,3-dipolar cycloaddition reaction with three oximes in the presence of chloramine-T when compared with the conventional method.
Synthesis of Pyrazole-linked Norcantharidin Analogues of Substituted Chromones
Wang, Wei,Deng, Liping,Tang, Shenlong,Qian, Qing
, p. 1631 - 1634 (2016/09/24)
Eighteen novel pyrazole-linked norcantharidin derivatives substituted by chromone ring were synthesized in a single step by the [3+2] 1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with hydrazone in the presence of chloramine-T as compared to the conventional method.
Containing chromon structure-isoxazole Norcantharidin derivative and its preparation method and application
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Paragraph 0020; 0032; 0034, (2017/02/02)
The invention discloses novel chromone structure containing isoxazole norcantharidin derivatives as well as a preparation method and an application thereof. The preparation method is characterized by introducing isoxazole rings to C5 and C6 in a norcantharidin structure by using a 1,3-dipolar cycloaddition method to react with chromone derivatives to import the chromone structures, thus synthesizing a series of totally six novel chromone structure containing isoxazole norcantharidin derivatives. The isoxazole norcantharidin derivatives are applied to synthesis of antitumor drugs and have broad application prospects.
Norcantharidin analogues - Synthesis and evaluation of growth inhibition in a panel of selected tumor-cell lines
Deng, Liping,Shen, Li,Zhang, Jing,Yang, Bo,He, Qiaojun,Hu, Yongzhou
, p. 938 - 944 (2008/03/28)
A series of norcantharidin (NCTD) analogues have been synthesized by [3+2]1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with four nitrile oximes. All analogues have been screened for their antiproliferative activity in vitro against a panel of tumor cell lines: KB, SGC-7901, HL60, Bel-7402, HO-8910, and ECA109, producing IC 50 values from 0.36 μmol/L to >100 μmol/L. Compound 9d showed potency for the treatment of hepatoma, with IC50 value to Bel-7402 cell line comparable to that of norcantharidin.
