746652-57-3

Upstream product

• 610272-49-6 (2S,3R)-1-benzyloxy-4,4,4-trifluoro-2,3-butanediol 
• 610272-47-4 (E)-(((4,4,4-trifluorobut-2-en-1-yl)oxy)methyl)benzene 
• 1863-63-4 ammonium benzoate 
• 610272-50-9 (3S,4R)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane 

Downstream Products

• 746652-64-2 (2S,3S)-benzoic acid 2-azido-1-benzyloxymethyl-3,3,3-trifluoropropyl ester 
• 746652-66-4 (2S,3S)-benzoic acid 2-azido-1-carboxy-3,3,3-trifluoropropyl ester 
• 746652-65-3 (2S,3S)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester 
• 746652-63-1 (2R,3R)-benzoic acid 1-benzyloxymethyl-3,3,3-trifluoro-2-trifluoromethanesulfonylpropyl ester 

Relevant academic research and scientific papers

Total synthesis of trifluoromethylated analogs of macrosphelide A

Trifluoromethylated analogs of macrosphelide A 1 and 2 were designed and synthesized. The key segment 6 was efficiently constructed via a series of high stereoselective transformations from trifluoromethylated diol 8. Methoxymethylation of compound 9 with

Regioselective and stereoselective nucleophilic ring opening of trifluoromethylated cyclic sulfates: Asymmetric synthesis of both enantiomers of syn-(3-trifluoromethyl)isoserine

A novel and efficient enantioselective synthesis of both enantiomers of syn-(3-trifluoromethyl)isoserine was achieved. Ring opening of trifluoromethylated cyclic sulfates 3, derived from enantiopure trifluoromethylated vicinal diols 2, with various nucleo