74668-38-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-N-(2-hydroxypropyl)benzenesulfonamide is used as a key intermediate in the synthesis of pharmaceutical compounds. Its drug-like properties and potential anti-inflammatory and anti-cancer activities make it a promising candidate for the development of new therapeutic agents.
Used in Drug Development:
4-Chloro-N-(2-hydroxypropyl)benzenesulfonamide is used as a potential therapeutic agent for anti-inflammatory and anti-cancer treatments. Its drug-like properties and potential therapeutic applications make it a valuable compound for further research and development in the pharmaceutical field.

Upstream product

• 5769-15-3 4-Chlorophenylsulfonyl isocyanate 
• 74668-36-3 (1-chloro-2-propyl) 4-chlorobenzenesulfonyl carbamate 
• 74668-37-4 3-(4-chlorobenzenesulfonyl)-5-methyloxazolidin-2-one 

Relevant academic research and scientific papers

Chemistry of Sulfonyl Isocyanates and Sulfonyl Isothiocyanates. IX. Routes to Substituted Oxazolidin-2-ones and Oxazolidine-2-thiones

4-Chlorobenzenesulfonyl isocyanate (I) reacted with 2-chloroethanol and 1-chloro-2-propanol to give, respectively, 2-choroethyl-4-chlorobenzenesulfonyl carbamate (III) and 1-chloro-2-propyl-4-chlorobenzenesulfonyl carbamate (VI).The carbamates III and VI cyclized under the influence of pyridine to afford, respectively, 3-(4-chlorobenzenesulfonyl)oxazolidin-2-one (IV) and 3-(4-chlorobenzenesulfonyl)-5-methyloxazolidin-2-one (VII).The oxazolidin-2-ones were stable toward hydrochloric acid but hydrolyzed in 2M sodium hydroxide solution to N-(2-hydroxyethyl)-4-chlorobenzenesulfonamide (V) and N-(2-hydroxy-1-propyl)-4-chlorobenzenesulfonamide (VIII), respectively. 4-Toluenesulfonyl isothiocyanate (II) reacted with 2-chloroethanol to give 2-chloroethyl-4-chlorobenzenesulfonyl thiocarbamate (IX), which was converted by pyridine to 3-(4-toluenesulfonyl)oxazolidine-2-thione. (X).