74684-11-0Relevant academic research and scientific papers
Total synthesis of tropoloisoquinolines: Imerubrine, isoimerubrine, and grandirubrine
Lee, Jae Chol,Cha, Jin Kun
, p. 3243 - 3246 (2007/10/03)
A unified, ready access to the tropoloisoquinoline alkaloids imerubrine (1), grandirubrine (2), and isoimerubrine (3) is delineated and features sequential application of the intramolecular Diels - Alder reaction of an acetylene-tethered oxazole and the [
Total synthesis of granditropone, grandirubrine, imerubrine, and isoimerubrine
Boger, Dale L.,Takahashi, Kanji
, p. 12452 - 12459 (2007/10/03)
Concise total syntheses of the naturally occurring tropoloisoquinolines grandirubrine (1), imerubrine (2), and isoimerubrine (3) are detailed. The regioselective total synthesis of grandirubrine (1) is based on the [4 + 2]cycloaddition reaction of the α-p
Preparation And Antileukemic Activity Of Congeners Of Tropoloisoquinoline Alkaloids From Abuta Concolor
Itokawa, Hideji,Matsumoto, Kouji,Morita, Hiroshi,Takeya, Koichi
, p. 1025 - 1032 (2007/10/02)
Antileukemic tropoloisoquinoline alkaloids, pareirubine A (1) and grandirubrine (2), at first have been isolated from Abuta concolor (Menispermaceae).Methylation of 1 and 2, existing in solution as a mixture of tautomers gave the corresponding four methyl derivatives (3 - 6).Thioimerubrine (7) and thioisoimerubrine (8) were prepared by the nucleophilic substitutions of the methoxyl groups at C-11 and -10, respectively.Acetylation of 1 and 2 produced the corresponding mono-acetyl tautomers (9 and 10).Antileukemic activity of these derived tropoloisoquinoline alkaloids is also reported.
GRANDIRUBRINE, A NEW TROPOLOISOQUINOLINE ALKALOID
Menachery, Mary D.,Cava, Michael P.
, p. 943 - 945 (2007/10/02)
Grandirubrine, a new alkaloid from Abuta grandifolia (Martius) Sandwith (Menispermaceae), has been assigned the tropoloisoquinoline structure I.
