74686-57-0

Basic information

• Product Name: (2E)-2-[(hydroxyamino)methylidene]pyridin-3(2H)-one
• CAS NO: 74686-57-0
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.124
• Mol File: 74686-57-0.mol

Chemical Properties

• Boiling Point: 311.5°C at 760 mmHg
• Flash Point: 142.2°C
• Density: 1.32g/cm³
• Vapor Pressure: 4.97E-05mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: (2E)-2-[(hydroxyamino)methylidene]pyridin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-2-[(hydroxyamino)methylidene]pyridin-3(2H)-one(74686-57-0)
• EPA Substance Registry System: (2E)-2-[(hydroxyamino)methylidene]pyridin-3(2H)-one(74686-57-0)

Safety Data

• Hazardous Substances Data: 74686-57-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-2-[(hydroxyamino)methylidene]pyridin-3(2H)-one is used as a building block for the synthesis of various organic compounds. Its unique structure and properties make it a promising candidate for the development of new pharmaceutical agents.
Used in Agricultural Industry:
(2E)-2-[(hydroxyamino)methylidene]pyridin-3(2H)-one may also have potential applications in the agricultural industry. Its ability to form various organic compounds can be utilized in the development of new agrochemicals, such as pesticides or herbicides, to improve crop protection and yield.

Upstream product

• 1849-55-4 2-Formyl-3-hydroxypyridin 

Relevant articles and documents

A HTS assay for the detection of organophosphorus nerve agent scavengers

A new pro-fluorescent probe aimed at a HTS assay of scavengers is able to selectively and efficiently cleave the P-S bond of organophosphorus nerve agents and by this provides non-toxic phosphonic acid has been designed and synthesised. The previously described pro-fluorescent probes were based on a conventional activated P-Oaryl bond cleavage, whereas our approach uses a self-immolative linker strategy that allows the detection of phosphonothioase activity with respect to a non-activated P-Salkyl bond. Further, we have also developed and optimised a high-throughput screening assay for the selection of decontaminants (chemical or biochemical scavengers) that could efficiently hydrolyse highly toxic V-type nerve agents. A preliminary screening, realised on a small α-nucleophile library, allowed us to identify some preliminary "hits", among which pyridinealdoximes, α-oxo oximes, hydroxamic acids and, less active but more original, amidoximes were the most promising. Their selective phosphonothioase activity has been further confirmed by using PhX as the substrate, and thus they offer new perspectives for the synthesis of more potent V nerve agent scavengers.