7469-81-0

Basic information

• Product Name: (1-bromocyclohexyl)(4-methoxyphenyl)methanone
• CAS NO: 7469-81-0
• Molecular Formula: C₁₄H₁₇BrO₂
• Molecular Weight: 297.1876
• Mol File: 7469-81-0.mol

Chemical Properties

• Boiling Point: 387.8°C at 760 mmHg
• Flash Point: 188.3°C
• Density: 1.349g/cm³
• Vapor Pressure: 3.21E-06mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: (1-bromocyclohexyl)(4-methoxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1-bromocyclohexyl)(4-methoxyphenyl)methanone(7469-81-0)
• EPA Substance Registry System: (1-bromocyclohexyl)(4-methoxyphenyl)methanone(7469-81-0)

Safety Data

• Hazardous Substances Data: 7469-81-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(1-bromocyclohexyl)(4-methoxyphenyl)methanone is used as a building block for the synthesis of various pharmaceuticals and bioactive molecules due to its unique structure and reactivity.
Used in Medicinal Chemistry:
(1-bromocyclohexyl)(4-methoxyphenyl)methanone is used as a starting material for the development of new drugs and pharmaceuticals, as it possesses potential biological activity and has been studied for its pharmacological properties.
Used in Pharmaceutical Industry:
(1-bromocyclohexyl)(4-methoxyphenyl)methanone is used as a valuable compound for research and development in the pharmaceutical industry, contributing to the discovery and creation of new therapeutic agents.

Upstream product

• 7469-80-9 cyclohexyl 4-methoxyphenyl ketone 

Downstream Products

• 469905-08-6 2-(4-methoxy-phenyl)-1-oxa-spiro[2.5]octane-2-carbonitrile 

Relevant articles and documents

Novel intermediate and processes for its preparation and conversion into a pharmacologically-active agent

Processes for the preparation of Venlafaxine (IX) via the novel epoxy-nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield the desired product (IX). The epoxy-nitrile intermediate (I) itself may be synthesised via various alternative reaction strategies, from a range of starting materials. E.g. 4-methoxy-benzaldehyde (VI), upon treatment with cyclohexyl magnesium bromide yields compound (V). This in turn may be oxidised to yield compound (III), which forms compound (II) on treatment with an (x-keto-halogenation agent. Cyanation of compound (II), then yields the desired epoxy nitrile intermediate (I), from which Venlafaxine (IX) may be synthesised.

Intermediate for the production of 1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol

Processes for the preparation of Venlafaxine (IX) via the novel epoxy-nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield the desired product (IX). The epoxy-nitrile intermediate (I) itself may be synthesised via various alternative reaction strategies, from a range of starting materials. E.g. 4-methoxy-benzaldehyde (VI), upon treatment with cyclohexyl magnesium bromide yields compound (V). This in turn may be oxidised to yield compound (III), which forms compound (II) on treatment with an α-keto-halogenation agent. Cyanation of compound (II), then yields the desired epoxy nitrile intermediate (I), from which Venlafaxine (IX) may be synthesised.